Gene: RPS18A - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | RPS18A | ||||||||||||||||||||||||
NCBI Gene ID | : | 852061 | ||||||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||
Gene Synonyms | : | |||||||||||||||||||||||||
Gene Homologs | : | AgaP_AGAP010375 (Anopheles gambiae) | AGOS_AER315C (Eremothecium gossypii) | AT1G34030 (Arabidopsis thaliana) | KLLA0B01562g (Kluyveromyces lactis) | LOC100360679 (Rattus norvegicus) | LOC462608 (Pan troglodytes) | MGG_05661 (Magnaporthe oryzae) | NCU00475 (Neurospora crassa) | Os03g0794700 (Oryza sativa) | Os07g0173700 (Oryza sativa) | PFL (Arabidopsis thaliana) | rps-18 (Caenorhabditis elegans) | RPS18 (Bos taurus) | RPS18 (Canis lupus familiaris) | rps18 (Danio rerio) | RpS18 (Drosophila melanogaster) | RPS18 (Homo sapiens) | RPS18 (Macaca mulatta) | Rps18 (Mus musculus) | RPS18 (Pan troglodytes) | Rps18 (Rattus norvegicus) | rps1801 (Schizosaccharomyces pombe) | rps1802 (Schizosaccharomyces pombe) | RPS18A (Saccharomyces cerevisiae) | RPS18B (Saccharomyces cerevisiae) | RPS18C (Arabidopsis thaliana) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_008718 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_005852 | Saccharomyces cerevisiae |
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increased | 15.00% | unknown | Deletion of both RPS18A and RPS18B paralogs increased replicative lifespan by 15%. | Chiocchetti et al. | 2007 | 17174052 | doi:10.1016/j.exger.2006.11.002 | GenAge | |||||||||||||||||||||||
2 | OB_000402 | Saccharomyces cerevisiae | BY4742 |
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none | -4.68% | 26.5 | 27.8 | divisions | mean | 30 | ℃ | matalpha | Supplemental Data Table | Steffen et al. | 2008 | 18423200 | doi:10.1016/j.cell.2008.02.037 | Lifespan Observations Database (ID: 1673) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Chiocchetti A, Zhou J, Zhu H, Karl T, Haubenreisser O, Rinnerthaler M, Heeren G, Oender K, Bauer J, Hintner H, Breitenbach M, Breitenbach-Koller L:
Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span.
Exp Gerontol. 2007; 42: 275-86.
PubMed (ID: 17174052), doi:10.1016/j.exger.2006.11.002
MeSH Terms: Ribosomal Protein S6/genetics; Ribosomal Proteins/genetics; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae/genetics - Steffen KK, MacKay VL, Kerr EO, Tsuchiya M, Hu D, Fox LA, Dang N, Johnston ED, Oakes JA, Tchao BN, Pak DN, Fields S, Kennedy BK, Kaeberlein M:
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.
Cell. 2008; 133: 292-302.
PubMed (ID: 18423200), PubMed Central (ID: PMC2749658), doi:10.1016/j.cell.2008.02.037
MeSH Terms: DNA-Binding Proteins/physiology; Ribosome Subunits, Large, Eukaryotic/physiology; Saccharomyces cerevisiae Proteins/physiology; Saccharomyces cerevisiae/physiology; Transcription Factors/physiology
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- NCBI Taxonomy
- PubMed