Gene: MEC1 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | MEC1 | ||||||||||||||||||||||||
NCBI Gene ID | : | 852433 | ||||||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||
Gene Synonyms | : | |||||||||||||||||||||||||
Gene Homologs | : | AGOS_ABR108C (Eremothecium gossypii) | KLLA0C15785g (Kluyveromyces lactis) | MEC1 (Saccharomyces cerevisiae) | MGG_02656 (Magnaporthe oryzae) | NCU11188 (Neurospora crassa) | rad3 (Schizosaccharomyces pombe) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_008763 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_005547 | Saccharomyces cerevisiae |
|
Mutants have a 3-fold reduced mean and maximum chronological lifespan under conditions of medium depletion. | 17710147 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_000784 | Saccharomyces cerevisiae |
|
increased | 300.00% | si | Mutants have a 3-fold reduced mean and maximum chronological lifespan under conditions of medium depletion. | Weinberger et al. | 2007 | 17710147 | doi:10.1371/journal.pone.0000748 | Lifespan Observations Database (ID: 2042) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009531 | 1 | The HomoloGene homology group 99739 contains 1 gene with experimental evidence for ageing relevance (MEC1 - Saccharomyces cerevisiae) and 5 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 99739 |
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Weinberger M, Feng L, Paul A, Smith DL, Hontz RD, Smith JS, Vujcic M, Singh KK, Huberman JA, Burhans WC:
DNA replication stress is a determinant of chronological lifespan in budding yeast.
PLoS ONE. 2007; 2: e748.
PubMed (ID: 17710147), PubMed Central (ID: PMC1939877), doi:10.1371/journal.pone.0000748
MeSH Terms: DNA Replication; Longevity/genetics; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/physiology; Stress, Physiological
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- NCBI Taxonomy
- PubMed