Release 1 - Aug 15, 2014

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Gene: C40H5.6 - Caenorhabditis elegans

Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Ageing relevance by experimental analysis: yes
Defined by: Gene Symbol, Species
Ageing relevance by experimental analysis: yes
Defined by: Gene Symbol, Species

Summary

Gene Symbol : C40H5.6
NCBI Gene ID :
Species : Caenorhabditis elegans
Gene Synonyms :
Gene Homologs :
Ageing Relevance Analysis :
Observation Type Count Ageing Relevance Source
Ageing Phenotype Observation—Data Type 2
Lifespan Effect
decreased 1 yes (Exp. Analysis) [Lifespan Observations Database icon]Lifespan Observations Database
increased 1 yes (Exp. Analysis) [Lifespan Observations Database icon]Lifespan Observations Database
Total 2
Ageing Factor Stable ID : AF_008844
Download : [xml icon]XML

* Ageing factors from different sources are merged, if possible. Genes are merged by their NCBI Gene ID, if assigned and otherwise by the combination of the gene symbol and species name. The latter approach is less reliable than using the NCBI Gene ID. This gene has no NCBI gene ID assigned. Therefore it is possible that it is already included in AgeFactDB under a different gene symbol or NCBI Gene ID. The missing NCBI Gene ID is also the reason for fact that one or more possible synonym groups are found.

Protein Information

no protein information available

Observations

Ageing Phenotype

Data Type 1

no ageing phenotype observation—data type 1 available

Data Type 2

Ageing Relevance:
  • yes (Exp. Analysis)
  • yes, but no ageing factor assigned (Exp. Analysis)
  • no (Exp. Analysis)
  • putative (Comp. Analysis)
Organism Ageing Factor Lifespan Observation Reference
# Observation Stable ID Species Strain Gene Compound Other Ageing Factor Significant Lifespan Effect Change Observed Lifespan Reference Lifespan Lifespan Unit Measure Temperature Temperature Unit Sex/Mating Type Description Author Year PubMed DOI Source
1 OB_001872 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
C40H5.6 Caenorhabditis elegans RNAi knockdown - unknown unknown
daf-2 Caenorhabditis elegans 175410 loss of function e1370 unknown unknown
increased 39.46% 20.5 14.7 days median 25 ℃ hermaphrodite A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. Samuelson et al. 2007 18006689 [DOI icon]doi:10.1101/gad.1588907 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 3185)
2 OB_001716 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
C40H5.6 Caenorhabditis elegans RNAi knockdown - unknown unknown
decreased -42.86% 8.4 14.7 days median 25 ℃ hermaphrodite A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. Samuelson et al. 2007 18006689 [DOI icon]doi:10.1101/gad.1588907 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 3044)
3 OB_001946 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
C40H5.6 Caenorhabditis elegans RNAi knockdown - unknown unknown
daf-16 Caenorhabditis elegans 172981 deletion / null mgDf47 unknown unknown
daf-2 Caenorhabditis elegans 175410 loss of function e1370 unknown unknown
decreased -43.54% 8.3 14.7 days median 25 ℃ hermaphrodite A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. Samuelson et al. 2007 18006689 [DOI icon]doi:10.1101/gad.1588907 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 3251)

Homology Analysis

no homology analysis observation available

Sequences

no sequence information available

References

MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.

  1. Samuelson AV, Carr CE, Ruvkun G:
    Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
    Genes Dev. 2007; 21: 2976-94.
    [PubMed icon]PubMed (ID: 18006689), [PubMed icon]PubMed Central (ID: PMC2049198), [DOI icon]doi:10.1101/gad.1588907
    MeSH Terms: Caenorhabditis elegans/physiology; Genes, Helminth; Insulin-Like Growth Factor I/genetics; Mutation; Signal Transduction/physiology

Sources

Ageing-related Data Sources

Additional Data Sources