1 |
OB_001827 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C27F2.5 |
Caenorhabditis elegans |
175672 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
increased |
72.79% |
25.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3144) |
2 |
OB_002514 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C27F2.5 |
Caenorhabditis elegans |
175672 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
43.00% |
|
|
|
|
|
|
|
RNA interference decreased median lifespan by 43% in wild type animals. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 376) |
3 |
OB_002525 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C27F2.5 |
Caenorhabditis elegans |
175672 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
33.00% |
|
|
|
|
|
|
|
RNA interference decreased median lifespan by 33% in a daf-2 background. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 377) |
4 |
OB_002536 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C27F2.5 |
Caenorhabditis elegans |
175672 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
9.00% |
|
|
|
|
|
|
|
RNA interference decreased median lifespan by 9% in daf-2/daf-16 double mutants. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 378) |
5 |
OB_001967 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C27F2.5 |
Caenorhabditis elegans |
175672 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-39.46% |
8.9 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3270) |
6 |
OB_001717 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C27F2.5 |
Caenorhabditis elegans |
175672 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-42.86% |
8.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3045) |
7 |
OB_006083 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C27F2.5 |
Caenorhabditis elegans |
175672 |
RNA interference |
- |
wildtype |
yes |
|
|
|
decreased |
-43.00% |
|
|
|
Median |
|
|
|
RNA interference decreased median lifespan by 43% in wild type animals, 33% in a daf-2 background and 9% in daf-2/daf-16 double mutants. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
GenAge |