Gene: pappa - Mus musculus(see also ageing factor AF_000758 *)
Summary
Gene Symbol | : | pappa | ||||||||||||||||
NCBI Gene ID | : | |||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||
Gene Synonyms | : | |||||||||||||||||
Gene Homologs | : | |||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_008919 | ||||||||||||||||
Download | : | XML |
* Ageing factors from different sources are merged, if possible. Genes are merged by their NCBI Gene ID, if assigned and otherwise by the combination of the gene symbol and species name. The latter approach is less reliable than using the NCBI Gene ID. This gene has no NCBI gene ID assigned. Therefore it is possible that it is already included in AgeFactDB under a different gene symbol or NCBI Gene ID. The missing NCBI Gene ID is also the reason for fact that one or more possible synonym groups are found.
AgeFactDB contains further genes associated with gene symbol pappa and the species Mus musculus: AF_000758
Protein Information
Observations
Ageing Phenotype
Data Type 1
Data Type 2
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_002852 | Mus musculus |
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increased | 37.54% | 960 | 698 | days | mean | Genetic deletion of PAPPA extended mean and maximum lifespan by 30-40%. Other phenotypes: Also reduced cancer incidence with no reduction in food intake or secondary endocrine abnormalities. Separation by sex showed significant increases in lifespan for both males (33%) and females (41%). | Conover et al. | 2007 | 17681037 | doi:10.1111/j.1474-9726.2007.00328.x | Lifespan Observations Database (ID: 4140) |
Homology Analysis
Sequences
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Conover CA, Bale LK:
Loss of pregnancy-associated plasma protein A extends lifespan in mice.
Aging Cell. 2007; 6: 727-9.
PubMed (ID: 17681037), doi:10.1111/j.1474-9726.2007.00328.x
MeSH Terms: Longevity/physiology; Pregnancy-Associated Plasma Protein-A/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- NCBI Taxonomy
- PubMed