Gene: LAT1 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
LAT1 |
NCBI Gene ID |
: |
855653 |
Species |
: |
Saccharomyces cerevisiae |
Gene Synonyms |
: |
|
Gene Homologs |
: |
AgaP_AGAP007975 (Anopheles gambiae) | AGOS_AER364W (Eremothecium gossypii) | AT1G54220.1 (Arabidopsis thaliana) | AT3G13930.1 (Arabidopsis thaliana) | CG5261 (Drosophila melanogaster) | DLAT (Bos taurus) | DLAT (Canis lupus familiaris) | dlat (Danio rerio) | DLAT (Gallus gallus) | DLAT (Homo sapiens) | DLAT (Macaca mulatta) | Dlat (Mus musculus) | DLAT (Pan troglodytes) | Dlat (Rattus norvegicus) | F23B12.5 (Caenorhabditis elegans) | KLLA0F04741g (Kluyveromyces lactis) | LAT1 (Saccharomyces cerevisiae) | lat1 (Schizosaccharomyces pombe) | MGG_09878 (Magnaporthe oryzae) | NCU07659 (Neurospora crassa) | Os02g0105200 (Oryza sativa) | Os06g0105400 (Oryza sativa) | Os07g0410100 (Oryza sativa) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenDR |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_008935 |
Download |
: |
XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005484 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
LAT1 |
855653 |
|
|
Deletion abolished the lifespan extension conferred by calorie restriction. Overexpression extended mean lifespan by 20%, did not further extend lifespan under CR, and was not dependent on the Sir2 family. Overexpression also extended cell survival during prolonged culture at stationary phase. |
17200108 |
GenAge |
2 |
OB_008002 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
LAT1 |
855653 |
|
Other Ageing Factor Name |
Dietary restriction |
|
LAT1 is suggested to play a role in lifespan extension of DR. Deleting LAT1 abolishes replicative lifespan extension induced by 0.5% and 0.05% glucose restriction. In contrast, overexpressing Lat1 extends replicative lifespan, and this lifespan extension was not further increased by 0.5% glucose restriction. Similar to DR, replicative lifespan extension by LAT1 overexpression largely requires mitochondrial respiration [ 17200108]. Overexpressing LAT1 extends lifespan (20% mean lifespan increase) and this lifespan extension is not further increased by DR. Similar to DR, lifespan extension by Lat1 overexpression largely requires mitochondrial respiration indicating mitochondrial metabolism plays an important role in DR. Interestingly, LAT1 overexpression does not require the Sir2 family to extend lifespan. Lat1 is also a limiting longevity factor in non-dividing cells in that overexpressing LAT1 extends cell survival during prolonged culture at stationary phase. |
17200108 |
GenDR |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_003032 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
LAT1 |
Saccharomyces cerevisiae |
855653 |
over-expression |
- |
unknown |
unknown |
|
|
|
increased |
20.00% |
|
|
|
mean |
|
|
|
Overexpression extended mean lifespan by 20%, did not further extend lifespan under CR, and was not dependent on the Sir2 family. Other phenotypes: Overexpression also extended cell survival during prolonged culture at stationary phase. |
Easlon et al. |
2007 |
17200108 |
doi:10.1074/jbc.M607661200 |
Lifespan Observations Database (ID: 4378) |
2 |
OB_005485 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
LAT1 |
Saccharomyces cerevisiae |
855653 |
Overexpression |
- |
wildtype |
yes |
|
|
|
increased |
20.00% |
|
|
|
Average |
|
|
|
Deletion abolished the lifespan extension conferred by calorie restriction. Overexpression extended mean lifespan by 20%, did not further extend lifespan under CR, and was not dependent on the Sir2 family. Overexpression also extended cell survival during prolonged culture at stationary phase. |
Easlon et al. |
2007 |
17200108 |
doi:10.1074/jbc.M607661200 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008834 |
|
1 |
The HomoloGene homology group 6814 contains 1 gene with experimental evidence for ageing relevance (LAT1 - Saccharomyces cerevisiae) and 22 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 6814 |
Sequences
no sequence information available
References
Sources
Ageing-related Data Sources
Additional Data Sources