Gene: Hsp27 - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Hsp27 | ||||||||||||||||||||||||
NCBI Gene ID | : | 39078 | ||||||||||||||||||||||||
Species | : | Drosophila melanogaster | ||||||||||||||||||||||||
Gene Synonyms | : | |||||||||||||||||||||||||
Gene Homologs | : | Hsp23 (Drosophila melanogaster) | Hsp26 (Drosophila melanogaster) | Hsp27 (Drosophila melanogaster) | Hsp67Ba (Drosophila melanogaster) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009014 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Heat shock protein 27 | Drosophila melanogaster | P02518 (UniProtKB/Swiss-Prot) | HSP27_DROME (UniProtKB/Swiss-Prot) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_005385 | Drosophila melanogaster |
|
Overexpression increased stress resistance and extended the mean lifespan by 30%. | 15308776 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_003823 | Drosophila melanogaster |
|
increased | 30.00% | Overexpression extended the mean lifespan by 30%. Other phenotypes: Overexpression increased stress resistance. | Wang et al. | 2004 | 15308776 | doi:10.1073/pnas.0404648101 | Lifespan Observations Database (ID: 547) | ||||||||||||||||||||||||
2 | OB_005386 | Drosophila melanogaster |
|
increased | 30.00% | Average | Overexpression increased stress resistance and extended the mean lifespan by 30%. | Wang et al. | 2004 | 15308776 | doi:10.1073/pnas.0404648101 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009071 |
|
2 | The HomoloGene homology group 119624 contains 2 genes with experimental evidence for ageing relevance (Hsp26 - Drosophila melanogaster | Hsp27 - Drosophila melanogaster) and 2 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 119624 |
Sequences
HSP27_DROME | P02518 | Heat shock protein 27 (Drosophila melanogaster) from UniProtKB/Swiss-Prot Length: 213 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 HSP27_DROME 1 MSIIPLLHLARELDHDYRTDWGHLLEDDFGFGVHAHDLFHPRRLLLPNTLGLGRRRYSPYERSHGHHNQMSRRASGGPNALLPAVGKDGFQVCMDVSQFKPNELTVKVVDNTVVVEGKHEEREDGHGMIQRHFVRKYTLPKGFDPNEVVSTVSSDGVLTLKAPPPPSKEQAKSERIVQIQQTGPAHLSVKAPAPEAGDGKAENGSGEKMETSK 213
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Wang HD, Kazemi-Esfarjani P, Benzer S:
Multiple-stress analysis for isolation of Drosophila longevity genes.
Proc Natl Acad Sci USA. 2004; 101: 12610-5.
PubMed (ID: 15308776), PubMed Central (ID: PMC515105), doi:10.1073/pnas.0404648101
MeSH Terms: Drosophila melanogaster/genetics; Heat-Shock Proteins/genetics; Hot Temperature; Longevity; Oxidants/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot