Compound: Methionine sulfoximine - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Methionine sulfoximine | ||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009061 | ||||||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004314 | Saccharomyces cerevisiae | BY4742 |
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increased | 22.92% | 31.1 | 25.3 | divisions | mean | 30 | ℃ | matalpha | Methionine sulfoximine (MSX) increases replicative life span of BY4742 mother cells. MSX is thought to inhibit TOR complex 1 activity by decreasing intracellular glutamine levels. | Kaeberlein et al. | 2005 | 16293764 | doi:10.1126/science.1115535 | Lifespan Observations Database (ID: 1096) | ||||||||
2 | OB_004315 | Saccharomyces cerevisiae | BY4742 |
|
increased | 19.37% | 30.2 | 25.3 | divisions | mean | 30 | ℃ | matalpha | Methionine sulfoximine (MSX) increases replicative life span of BY4742 mother cells. MSX is thought to inhibit TOR complex 1 activity by decreasing intracellular glutamine levels. | Kaeberlein et al. | 2005 | 16293764 | doi:10.1126/science.1115535 | Lifespan Observations Database (ID: 1097) | ||||||||
3 | OB_004318 | Saccharomyces cerevisiae | BY4742 |
|
increased | 12.65% | 28.5 | 25.3 | divisions | mean | 30 | ℃ | matalpha | Methionine sulfoximine (MSX) increases replicative life span of BY4742 mother cells at 0.1-1 mM. MSX is thought to inhibit TOR complex 1 activity by decreasing intracellular glutamine levels. Concentrations of MSX higher than 2.5 mM do not significantly extend life span and 10 mM MSX shortens replicative life span. | Kaeberlein et al. | 2005 | 16293764 | doi:10.1126/science.1115535 | Lifespan Observations Database (ID: 1100) | ||||||||
4 | OB_004316 | Saccharomyces cerevisiae | BY4742 |
|
increased | 6.72% | 27 | 25.3 | divisions | mean | 30 | ℃ | matalpha | Methionine sulfoximine (MSX) increases replicative life span of BY4742 mother cells at 0.1-1 mM. MSX is thought to inhibit TOR complex 1 activity by decreasing intracellular glutamine levels. Concentrations of MSX higher than 2.5 mM do not significantly extend life span and 10 mM MSX shortens replicative life span. | Kaeberlein et al. | 2005 | 16293764 | doi:10.1126/science.1115535 | Lifespan Observations Database (ID: 1098) | ||||||||
5 | OB_004317 | Saccharomyces cerevisiae | BY4742 |
|
decreased | -56.92% | 10.9 | 25.3 | divisions | mean | 30 | ℃ | matalpha | Methionine sulfoximine (MSX) increases replicative life span of BY4742 mother cells at 0.1-1 mM. MSX is thought to inhibit TOR complex 1 activity by decreasing intracellular glutamine levels. Concentrations of MSX higher than 2.5 mM do not significantly extend life span and 10 mM MSX shortens replicative life span. | Kaeberlein et al. | 2005 | 16293764 | doi:10.1126/science.1115535 | Lifespan Observations Database (ID: 1099) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kaeberlein M, Powers RW, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK:
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Science. 2005; 310: 1193-6.
PubMed (ID: 16293764), doi:10.1126/science.1115535
MeSH Terms: Protein Kinases/metabolism; Saccharomyces cerevisiae Proteins/physiology; Saccharomyces cerevisiae/physiology