1 |
OB_000148 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
31.03% |
34.2 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1160) |
2 |
OB_000108 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
25.27% |
34.2 |
27.3 |
divisions |
mean |
30 |
℃ |
matalpha |
Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. |
Kaeberlein et al. |
2005 |
16311627 |
doi:10.1371/journal.pgen.0010069 |
Lifespan Observations Database (ID: 1119) |
3 |
OB_000146 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
increased |
5.75% |
27.6 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1159) |
4 |
OB_000165 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
none |
2.30% |
26.7 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1176) |
5 |
OB_000111 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
none |
1.10% |
27.6 |
27.3 |
divisions |
mean |
30 |
℃ |
matalpha |
Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. |
Kaeberlein et al. |
2005 |
16311627 |
doi:10.1371/journal.pgen.0010069 |
Lifespan Observations Database (ID: 1121) |
6 |
OB_000164 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
none |
-2.30% |
25.5 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1175) |
7 |
OB_004393 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
25 |
mM |
|
|
decreased |
-29.53% |
13.6 |
19.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Growing worms on Nam results in a shorter mean lifespan compared to growing N2 in the absence of Nam. |
van der Horst et al. |
2007 |
17335870 |
doi:10.1016/j.mad.2007.01.004 |
Lifespan Observations Database (ID: 3525) |
8 |
OB_002250 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
25 |
mM |
|
|
decreased |
-40.41% |
11.5 |
19.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Growing mutant worms on Nam results in no significant difference in lifespan compared to growing mutant worms in the absence of Nam. |
van der Horst et al. |
2007 |
17335870 |
doi:10.1016/j.mad.2007.01.004 |
Lifespan Observations Database (ID: 3526) |
9 |
OB_004319 |
Saccharomyces cerevisiae |
BY4742 |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
decreased |
-41.41% |
15 |
25.6 |
divisions |
mean |
30 |
℃ |
matalpha |
Addition of 5 mM nicotinamide shortens replicative life span in the BY4742 strain background to the same extent as deletion of SIR2. The combination of SIR2 deletion with 5 mM nicotinamide does not further shorten life span. This indicates that 5 mM nicotinamide is likely reducing life span by inhibition of SIR2. |
Kaeberlein et al. |
2005 |
16311627 |
doi:10.1371/journal.pgen.0010069 |
Lifespan Observations Database (ID: 1117) |
10 |
OB_000106 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
decreased |
-44.14% |
14.3 |
25.6 |
divisions |
mean |
30 |
℃ |
matalpha |
Addition of 5 mM nicotinamide shortens replicative life span in the BY4742 strain background to the same extent as deletion of SIR2. The combination of SIR2 deletion with 5 mM nicotinamide does not further shorten life span. This indicates that 5 mM nicotinamide is likely reducing life span by inhibition of SIR2. |
Kaeberlein et al. |
2005 |
16311627 |
doi:10.1371/journal.pgen.0010069 |
Lifespan Observations Database (ID: 1116) |
11 |
OB_000137 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
decreased |
-49.43% |
13.2 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1150) |
12 |
OB_000129 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
decreased |
-54.02% |
12 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1143) |
13 |
OB_002251 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
25 |
mM |
|
|
decreased |
-66.84% |
6.4 |
19.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Growing mutant worms on Nam results in a shorter mean lifespan (6.4 days) relative to mutant lifespan without Nam (33.5 days). |
van der Horst et al. |
2007 |
17335870 |
doi:10.1016/j.mad.2007.01.004 |
Lifespan Observations Database (ID: 3527) |
14 |
OB_000135 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
25 |
millimolar |
|
|
decreased |
-72.80% |
7.1 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1149) |
15 |
OB_000133 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
decreased |
-83.52% |
4.3 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1147) |
16 |
OB_000134 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
25 |
millimolar |
|
|
decreased |
-83.91% |
4.2 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1148) |
17 |
OB_000141 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
25 |
millimolar |
|
|
decreased |
-84.67% |
4 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1154) |
18 |
OB_000140 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
decreased |
-85.82% |
3.7 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1153) |
19 |
OB_004454 |
Saccharomyces cerevisiae |
BY4741 |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
1 |
mM |
|
|
decreased |
|
|
|
days |
max |
30 |
℃ |
mata |
Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. |
Smith et al. |
2007 |
17711561 |
doi:10.1111/j.1474-9726.2007.00326.x |
Lifespan Observations Database (ID: 4177) |
20 |
OB_004455 |
Saccharomyces cerevisiae |
BY4741 |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
mM |
|
|
decreased |
|
|
|
days |
max |
30 |
℃ |
mata |
Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. |
Smith et al. |
2007 |
17711561 |
doi:10.1111/j.1474-9726.2007.00326.x |
Lifespan Observations Database (ID: 4178) |