Compound: Cycloheximide - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Cycloheximide | ||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009063 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004322 | Saccharomyces cerevisiae | BY4742 |
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decreased | -6.20% | 22.7 | 24.2 | divisions | mean | 30 | ℃ | matalpha | Treatment of yeast cells with the translation inhibitor cycloheximide either had no significant effect or shortened life span at concentrations from 10 ng/mL - 100 ng/mL. From Supplemental Figure 4. | Steffen et al. | 2008 | 18423200 | doi:10.1016/j.cell.2008.02.037 | Lifespan Observations Database (ID: 1264) | ||||||||
2 | OB_004323 | Saccharomyces cerevisiae | BY4742 |
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decreased | -9.92% | 21.8 | 24.2 | divisions | mean | 30 | ℃ | matalpha | Treatment of yeast cells with the translation inhibitor cycloheximide either had no significant effect or shortened life span at concentrations from 10 ng/mL - 100 ng/mL. From Supplemental Figure 4. | Steffen et al. | 2008 | 18423200 | doi:10.1016/j.cell.2008.02.037 | Lifespan Observations Database (ID: 1265) | ||||||||
3 | OB_004320 | Saccharomyces cerevisiae | BY4742 |
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decreased | -13.77% | 21.3 | 24.7 | divisions | mean | 30 | ℃ | matalpha | Treating cells with diazaborine, a specific inhibitor of 60S maturation, significantly increase replicative life span, while treatment with the general translation inhibitor cycloheximide did not. | Steffen et al. | 2008 | 18423200 | doi:10.1016/j.cell.2008.02.037 | Lifespan Observations Database (ID: 1249) | ||||||||
4 | OB_004324 | Saccharomyces cerevisiae | BY4742 |
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decreased | -15.70% | 20.4 | 24.2 | divisions | mean | 30 | ℃ | matalpha | Treatment of yeast cells with the translation inhibitor cycloheximide either had no significant effect or shortened life span at concentrations from 10 ng/mL - 100 ng/mL. From Supplemental Figure 4. | Steffen et al. | 2008 | 18423200 | doi:10.1016/j.cell.2008.02.037 | Lifespan Observations Database (ID: 1266) | ||||||||
5 | OB_004325 | Saccharomyces cerevisiae | BY4742 |
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decreased | -37.60% | 15.1 | 24.2 | divisions | mean | 30 | ℃ | matalpha | Treatment of yeast cells with the translation inhibitor cycloheximide either had no significant effect or shortened life span at concentrations from 10 ng/mL - 100 ng/mL. From Supplemental Figure 4. | Steffen et al. | 2008 | 18423200 | doi:10.1016/j.cell.2008.02.037 | Lifespan Observations Database (ID: 1267) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Steffen KK, MacKay VL, Kerr EO, Tsuchiya M, Hu D, Fox LA, Dang N, Johnston ED, Oakes JA, Tchao BN, Pak DN, Fields S, Kennedy BK, Kaeberlein M:
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.
Cell. 2008; 133: 292-302.
PubMed (ID: 18423200), PubMed Central (ID: PMC2749658), doi:10.1016/j.cell.2008.02.037
MeSH Terms: DNA-Binding Proteins/physiology; Ribosome Subunits, Large, Eukaryotic/physiology; Saccharomyces cerevisiae Proteins/physiology; Saccharomyces cerevisiae/physiology; Transcription Factors/physiology