Compound: Recombinant human IGF-1 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Recombinant human IGF-1 | ||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009066 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004327 | Mus musculus | Zmpste24-/- |
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increased | 16.67% | 140 | 120 | days | median | Zmpste24-/- knockout mice treated with recombinant human IGF-1 had their short life span extended.Zmpste24 (also called FACE-1) is a metalloproteinase involved in the maturation of lamin A, an essential component of the nuclear envelope. Zmpste24-deficient mice exhibit multiple defects that phenocopy human accelerated aging processes such as Hutchinson Gilford progeria syndrome.[ 11923874] | Mariño et al. | 2010 | 20805469 | doi:10.1073/pnas.1002696107 | Lifespan Observations Database (ID: 2035) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Mariño G, Ugalde AP, Fernández AF, Osorio FG, Fueyo A, Freije JM, López-Otín C:
Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.
Proc Natl Acad Sci USA. 2010; 107: 16268-73.
PubMed (ID: 20805469), PubMed Central (ID: PMC2941281), doi:10.1073/pnas.1002696107
MeSH Terms: Aging, Premature/drug therapy; Insulin-Like Growth Factor I/therapeutic use; Longevity/drug effects; Somatotrophs/drug effects