1 |
OB_004498 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
mg |
|
|
increased |
66.67% |
12.5 |
7.5 |
days |
mean |
25 |
℃ |
|
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with 240 ml of liposomes containing 10 mg N-acetyl-cystein (NAC) was 46% greater than control. |
Shibamura et al. |
2009 |
19580823 |
doi:10.1016/j.mad.2009.06.008 |
Lifespan Observations Database (ID: 4650) |
2 |
OB_004496 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2.5 |
mg |
|
|
increased |
46.67% |
11 |
7.5 |
days |
mean |
25 |
℃ |
|
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with 240 ml of liposomes containing 2.5 mg N-acetyl-cystein (NAC) was 46% greater than control. |
Shibamura et al. |
2009 |
19580823 |
doi:10.1016/j.mad.2009.06.008 |
Lifespan Observations Database (ID: 4648) |
3 |
OB_004497 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
5 |
mg |
|
|
increased |
46.67% |
11 |
7.5 |
days |
mean |
25 |
℃ |
|
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with 240 ml of liposomes containing 5 mg N-acetyl-cystein (NAC) was 46% greater than control. |
Shibamura et al. |
2009 |
19580823 |
doi:10.1016/j.mad.2009.06.008 |
Lifespan Observations Database (ID: 4649) |
4 |
OB_008084 |
Caenorhabditis elegans |
pmk-1(km25) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
RNAi knockdown |
no |
pmk-1 |
Caenorhabditis elegans |
191743 |
loss of function |
km25 |
loss of function |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
increased |
45.00% |
55 |
38 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
5 |
OB_008088 |
Caenorhabditis elegans |
skn-1(zu67) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
RNAi knockdown |
no |
skn-1 |
Caenorhabditis elegans |
177343 |
unknown |
zu67 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
increased |
34.00% |
45.5 |
34 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
6 |
OB_008113 |
Caenorhabditis elegans |
pmk-1(km25) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
RNAi knockdown |
no |
pmk-1 |
Caenorhabditis elegans |
191743 |
loss of function |
km25 |
loss of function |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
increased |
26.00% |
34.13 |
27.02 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
7 |
OB_008117 |
Caenorhabditis elegans |
skn-1(zu67) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
RNAi knockdown |
no |
skn-1 |
Caenorhabditis elegans |
177343 |
unknown |
zu67 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
increased |
22.00% |
26.71 |
21.89 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
8 |
OB_004348 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
g/l of drinking water |
|
|
increased |
21.95% |
1000 |
820 |
days |
median |
|
|
male |
A heterogeneous stock of mice, UM-HET3 (the first generation offspring of CByB6F1/J and C3D2F1/J parents) were used to test effects of six antiaging treatments on life span. In the first report of diet restriction in a structured, segregating heterogeneous population, essentially the same increases in mean and maximum life span as found in CByB6F1/J hybrid positive controls were observed. The results of treatment with N-acetyl-L-cysteine started at 7 months, and aspirin, nitroflurbiprofen, 4-hydroxy phenyl N-tert-butyl nitrone, and nordihydroguaiaretic acid, all started at 16-18 months are also reported. Only male UM-HET3 mice receiving N-acetyl-L-cysteine had significantly increased life span, and this may have been due to treatment-related inadvertent diet restriction. The other agents had no significant effects on life span. The use of UM-HET3 mice helps assure that these results are not the result of unresponsiveness of a single genotype but that they more broadly represent laboratory mice. |
Flurkey et al. |
2010 |
20819793 |
doi:10.1093/gerona/glq155 |
Lifespan Observations Database (ID: 2275) |
9 |
OB_004499 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
5 |
mg |
|
|
increased |
13.33% |
8.5 |
7.5 |
days |
mean |
25 |
℃ |
|
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with NGM (without liposomes) containing 5 mg N-acetyl-cystein (NAC) was not significantly different than control. |
Shibamura et al. |
2009 |
19580823 |
doi:10.1016/j.mad.2009.06.008 |
Lifespan Observations Database (ID: 4651) |
10 |
OB_004347 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
5 |
g/l of drinking water |
|
|
increased |
12.20% |
920 |
820 |
days |
median |
|
|
male |
A heterogeneous stock of mice, UM-HET3 (the first generation offspring of CByB6F1/J and C3D2F1/J parents) were used to test effects of six antiaging treatments on life span. In the first report of diet restriction in a structured, segregating heterogeneous population, essentially the same increases in mean and maximum life span as found in CByB6F1/J hybrid positive controls were observed. The results of treatment with N-acetyl-L-cysteine started at 7 months, and aspirin, nitroflurbiprofen, 4-hydroxy phenyl N-tert-butyl nitrone, and nordihydroguaiaretic acid, all started at 16-18 months are also reported. Only male UM-HET3 mice receiving N-acetyl-L-cysteine had significantly increased life span, and this may have been due to treatment-related inadvertent diet restriction. The other agents had no significant effects on life span. The use of UM-HET3 mice helps assure that these results are not the result of unresponsiveness of a single genotype but that they more broadly represent laboratory mice. |
Flurkey et al. |
2010 |
20819793 |
doi:10.1093/gerona/glq155 |
Lifespan Observations Database (ID: 2274) |
11 |
OB_004570 |
Caenorhabditis elegans |
clk-1(qm30) |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
mM |
|
|
increased |
11.11% |
23 |
20.7 |
days |
mean |
20 |
℃ |
|
Treatment of N2 worms with N-acetyl-cysteine had no significant effect on lifespan. NAC treatment slightly increased lifespan of clk-1 mutants relative to mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5103) |
12 |
OB_004567 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
mM |
|
|
increased |
9.78% |
20.2 |
18.4 |
days |
mean |
20 |
℃ |
|
Treatment of N2 worms with N-acetyl-cysteine had no significant effect on lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5100) |
13 |
OB_008080 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
RNAi knockdown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
increased |
6.00% |
38 |
36 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
14 |
OB_008083 |
Caenorhabditis elegans |
pmk-1(km25) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pmk-1 |
Caenorhabditis elegans |
191743 |
loss of function |
km25 |
loss of function |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
increased |
5.00% |
29.5 |
28 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
15 |
OB_008087 |
Caenorhabditis elegans |
skn-1(zu67) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
skn-1 |
Caenorhabditis elegans |
177343 |
unknown |
zu67 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
increased |
5.00% |
22.5 |
21.5 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
16 |
OB_004573 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
mM |
|
|
none |
3.45% |
30 |
29 |
days |
max |
20 |
℃ |
|
Treatment of 10 mM NAC (N-acetyl-cysteine) had no significant difference on maximum lifespan of N2 worms. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5106) |
17 |
OB_008109 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
RNAi knockdown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
none |
1.00% |
21.13 |
21.02 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
18 |
OB_004345 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
g/l of drinking water |
|
|
none |
0.00% |
920 |
920 |
days |
median |
|
|
female |
A heterogeneous stock of mice, UM-HET3 (the first generation offspring of CByB6F1/J and C3D2F1/J parents) were used to test effects of six antiaging treatments on life span. In the first report of diet restriction in a structured, segregating heterogeneous population, essentially the same increases in mean and maximum life span as found in CByB6F1/J hybrid positive controls were observed. The results of treatment with N-acetyl-L-cysteine started at 7 months, and aspirin, nitroflurbiprofen, 4-hydroxy phenyl N-tert-butyl nitrone, and nordihydroguaiaretic acid, all started at 16-18 months are also reported. Only male UM-HET3 mice receiving N-acetyl-L-cysteine had significantly increased life span, and this may have been due to treatment-related inadvertent diet restriction. The other agents had no significant effects on life span. The use of UM-HET3 mice helps assure that these results are not the result of unresponsiveness of a single genotype but that they more broadly represent laboratory mice. |
Flurkey et al. |
2010 |
20819793 |
doi:10.1093/gerona/glq155 |
Lifespan Observations Database (ID: 2272) |
19 |
OB_004346 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
5 |
g/l of drinking water |
|
|
none |
0.00% |
920 |
920 |
days |
median |
|
|
female |
A heterogeneous stock of mice, UM-HET3 (the first generation offspring of CByB6F1/J and C3D2F1/J parents) were used to test effects of six antiaging treatments on life span. In the first report of diet restriction in a structured, segregating heterogeneous population, essentially the same increases in mean and maximum life span as found in CByB6F1/J hybrid positive controls were observed. The results of treatment with N-acetyl-L-cysteine started at 7 months, and aspirin, nitroflurbiprofen, 4-hydroxy phenyl N-tert-butyl nitrone, and nordihydroguaiaretic acid, all started at 16-18 months are also reported. Only male UM-HET3 mice receiving N-acetyl-L-cysteine had significantly increased life span, and this may have been due to treatment-related inadvertent diet restriction. The other agents had no significant effects on life span. The use of UM-HET3 mice helps assure that these results are not the result of unresponsiveness of a single genotype but that they more broadly represent laboratory mice. |
Flurkey et al. |
2010 |
20819793 |
doi:10.1093/gerona/glq155 |
Lifespan Observations Database (ID: 2273) |
20 |
OB_008112 |
Caenorhabditis elegans |
pmk-1(km25) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pmk-1 |
Caenorhabditis elegans |
191743 |
loss of function |
km25 |
loss of function |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
none |
0.00% |
19.42 |
19.36 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
21 |
OB_008108 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
none |
-1.00% |
16.65 |
16.78 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
22 |
OB_008116 |
Caenorhabditis elegans |
skn-1(zu67) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
skn-1 |
Caenorhabditis elegans |
177343 |
unknown |
zu67 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
none |
-1.00% |
16.57 |
16.77 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
23 |
OB_008079 |
Caenorhabditis elegans |
aak-2(ok524) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
unknown |
ok524 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
none |
-2.00% |
24 |
24.5 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
24 |
OB_008125 |
Caenorhabditis elegans |
daf-16(mu86) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
null mutant |
mu86 |
null mutant |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
none |
-2.00% |
16.35 |
16.71 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
25 |
OB_008156 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
1 |
mM |
|
|
none |
-2.00% |
18.96 |
19.4 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
26 |
OB_008154 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
1 |
mM |
|
|
none |
-3.00% |
27.3 |
28 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
27 |
OB_008096 |
Caenorhabditis elegans |
daf-16(mu86) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
null mutant |
mu86 |
null mutant |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
decreased |
-6.00% |
22.5 |
24 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
28 |
OB_004576 |
Caenorhabditis elegans |
clk-1(qm30) |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
mM |
|
|
decreased |
-6.25% |
30 |
32 |
days |
max |
20 |
℃ |
|
Treatment of 10 mM NAC (N-acetyl-cysteine) had shortened maximum lifespan of clk-1(qm30) mutant worms by approximately 6% relative to mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5109) |
29 |
OB_008104 |
Caenorhabditis elegans |
daf-2(e1370) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
unknown |
e1370 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
decreased |
-12.00% |
44.87 |
51.09 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
30 |
OB_008073 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
RNAi knockdown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
decreased |
-14.00% |
60.3 |
70.3 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
31 |
OB_004571 |
Caenorhabditis elegans |
daf-2(e1370) |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
mM |
|
|
decreased |
-14.84% |
37.3 |
43.8 |
days |
mean |
20 |
℃ |
|
Treatment of N2 worms with N-acetyl-cysteine had no significant effect on lifespan. NAC treatment slightly decreased lifespan of daf-2 mutants relative to mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5104) |
32 |
OB_008102 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
RNAi knockdown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
decreased |
-15.00% |
39.64 |
46.76 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
33 |
OB_008075 |
Caenorhabditis elegans |
daf-2(e1370) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
unknown |
e1370 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
decreased |
-16.00% |
61.5 |
73.5 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
34 |
OB_004572 |
Caenorhabditis elegans |
sod-2 |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
mM |
|
|
decreased |
-16.67% |
20 |
24 |
days |
mean |
20 |
℃ |
|
Treatment of N2 worms with N-acetyl-cysteine had no significant effect on lifespan. NAC treatment slightly decreased lifespan of sod-2 mutants relative to mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5105) |
35 |
OB_008077 |
Caenorhabditis elegans |
age-1(hx546) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
decreased |
-19.00% |
41 |
50.5 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
36 |
OB_008106 |
Caenorhabditis elegans |
age-1(hx546) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
decreased |
-19.00% |
23.46 |
28.9 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
37 |
OB_004577 |
Caenorhabditis elegans |
daf-2(e1370) |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
mM |
|
|
decreased |
-19.40% |
54 |
67 |
days |
max |
20 |
℃ |
|
Treatment of 10 mM NAC (N-acetyl-cysteine) had shortened maximum lifespan of daf-2(e1370) mutant worms by approximately 20% relative to mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5110) |
38 |
OB_004569 |
Caenorhabditis elegans |
isp-1(qm150) |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
mM |
|
|
decreased |
-24.48% |
25.6 |
33.9 |
days |
mean |
20 |
℃ |
|
Treatment of N2 worms with N-acetyl-cysteine had no significant effect on lifespan. NAC treatment limited the increased longevity of isp-1, decreasing lifespan approximately 30%l. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5102) |
39 |
OB_004575 |
Caenorhabditis elegans |
isp-1(qm150) |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
mM |
|
|
decreased |
-28.30% |
38 |
53 |
days |
max |
20 |
℃ |
|
Treatment of 10 mM NAC (N-acetyl-cysteine) had shortened maximum lifespan of isp-1(qm150) mutant worms by approximately 28% relative to mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5108) |
40 |
OB_004568 |
Caenorhabditis elegans |
nuo-6(qm200) |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
mM |
|
|
decreased |
-38.02% |
20.7 |
33.4 |
days |
mean |
20 |
℃ |
|
Treatment of N2 worms with N-acetyl-cysteine had no significant effect on lifespan. NAC treatment fully abolished the increased longevity of nuo-6, decreasing lifespan 35% to that of N2 control. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5101) |
41 |
OB_004574 |
Caenorhabditis elegans |
nuo-6(qm200) |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
10 |
mM |
|
|
decreased |
-40.82% |
29 |
49 |
days |
max |
20 |
℃ |
|
Treatment of 10 mM NAC (N-acetyl-cysteine) had shortened maximum lifespan of nuo-6(qm200) mutant worms by approximately 40%. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5107) |