1 |
OB_004373 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
increased |
50.00% |
27 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2476) |
2 |
OB_004374 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
increased |
45.56% |
26.2 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2477) |
3 |
OB_001159 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad465 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
increased |
38.33% |
24.9 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2489) |
4 |
OB_001154 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
eat-2 |
Caenorhabditis elegans |
175072 |
unknown |
ad465 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
increased |
32.22% |
23.8 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2484) |
5 |
OB_004367 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
increased |
24.42% |
27 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2470) |
6 |
OB_004368 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
increased |
23.04% |
26.7 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2471) |
7 |
OB_004372 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
increased |
18.89% |
21.4 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2475) |
8 |
OB_004371 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
increased |
17.22% |
21.1 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2474) |
9 |
OB_001164 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sir-2.1 |
Caenorhabditis elegans |
177924 |
loss of function |
ok434 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
increased |
11.67% |
20.1 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2493) |
10 |
OB_004370 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
increased |
8.89% |
19.6 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2473) |
11 |
OB_004366 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
none |
1.84% |
22.1 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2469) |
12 |
OB_004365 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
none |
-2.30% |
21.2 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2468) |
13 |
OB_001148 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sir-2.1 |
Caenorhabditis elegans |
177924 |
loss of function |
ok434 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
decreased |
-5.56% |
17 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2479) |
14 |
OB_004364 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
decreased |
-6.45% |
20.3 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2467) |
15 |
OB_001163 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf50 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
decreased |
-7.22% |
16.7 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2492) |
16 |
OB_001152 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf50 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
decreased |
-9.28% |
16.33 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2482) |
17 |
OB_001158 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hsf-1 |
Caenorhabditis elegans |
173078 |
loss of function |
sy441 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
decreased |
-10.00% |
16.2 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2488) |
18 |
OB_001155 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hsf-1 |
Caenorhabditis elegans |
173078 |
loss of function |
sy441 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
decreased |
-17.78% |
14.8 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2485) |
19 |
OB_004375 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
decreased |
-33.89% |
11.9 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2478) |
20 |
OB_004369 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
decreased |
-45.62% |
11.8 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2472) |