Compound: Porcine growth hormone - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Porcine growth hormone | ||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||
Ageing Relevance Analysis | : |
|
||||||||||||||||
Ageing Factor Stable ID | : | AF_009079 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||||||||
1 | OB_001167 | Mus musculus | heterogeneous genetic background |
|
|
increased | 6.48% | 707 | 664 | days | median | male | Hypopituitary Ames dwarf mice were injected either with growth hormone (GH) or thyroxine for a 6-wk period to see whether this intervention would reverse their long life span or the resistance of their cells to lethal stresses. Ames dwarf mice survived 987 days (median), longer than non-mutant control mice (664 days), but GH-injected dwarf mice did not differ from controls (707 days). T4 injections into Ames dwarf mice, in contrast, did not restore normal life span.Ames dwarf (df/df) mice are GH deficient due to their homozygosity for a recessive loss-of-function mutation at the Prop1 locus (Prop1df). | Panici et al. | 2010 | 20720157 | doi:10.1096/fj.10-163253 | Lifespan Observations Database (ID: 2496) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Panici JA, Harper JM, Miller RA, Bartke A, Spong A, Masternak MM:
Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice.
FASEB J. 2010; 24: 5073-9.
PubMed (ID: 20720157), PubMed Central (ID: PMC2992365), doi:10.1096/fj.10-163253
MeSH Terms: Growth Hormone/pharmacology; Longevity/drug effects