Compound: 4,5,6,7-tetrabromo-benzimidazole - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name |
: |
4,5,6,7-tetrabromo-benzimidazole |
Species |
: |
Saccharomyces cerevisiae |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Total |
1 |
|
|
|
Ageing Factor Stable ID |
: |
AF_009081 |
Download |
: |
XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_004383 |
Saccharomyces cerevisiae |
DBY746 |
|
Compound Name |
Quantity |
Quantity Unit |
4,5,6,7-tetrabromo-benzimidazole |
10 |
micromolar |
|
|
increased |
40.00% |
7 |
5 |
days |
median |
30 |
℃ |
mata |
4,5,6,7-tetrabromo-benzimidazole inhibits the serine-threonine kinase CK2 and increases chronological life span. |
Fabrizio et al. |
2010 |
20657825 |
doi:10.1371/journal.pgen.1001024 |
Lifespan Observations Database (ID: 2676) |
2 |
OB_004384 |
Saccharomyces cerevisiae |
DBY746 |
|
Compound Name |
Quantity |
Quantity Unit |
4,5,6,7-tetrabromo-benzimidazole |
50 |
micromolar |
|
|
increased |
20.00% |
6 |
5 |
days |
median |
30 |
℃ |
mata |
4,5,6,7-tetrabromo-benzimidazole inhibits the serine-threonine kinase CK2 and increases chronological life span. |
Fabrizio et al. |
2010 |
20657825 |
doi:10.1371/journal.pgen.1001024 |
Lifespan Observations Database (ID: 2677) |
3 |
OB_004385 |
Saccharomyces cerevisiae |
DBY746 |
|
Compound Name |
Quantity |
Quantity Unit |
4,5,6,7-tetrabromo-benzimidazole |
200 |
micromolar |
|
|
increased |
20.00% |
6 |
5 |
days |
median |
30 |
℃ |
mata |
4,5,6,7-tetrabromo-benzimidazole inhibits the serine-threonine kinase CK2 and increases chronological life span. |
Fabrizio et al. |
2010 |
20657825 |
doi:10.1371/journal.pgen.1001024 |
Lifespan Observations Database (ID: 2678) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD:
Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.
PLoS Genet. 2010; 6: e1001024.
PubMed (ID: 20657825), PubMed Central (ID: PMC2904796), doi:10.1371/journal.pgen.1001024
MeSH Terms: Genome, Fungal; Longevity/genetics; Saccharomyces cerevisiae/genetics
Sources
Ageing-related Data Sources
Additional Data Sources