1 |
OB_001464 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
normal |
e1370 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trehalose |
5 |
mM |
|
|
increased |
114.87% |
57.8 |
26.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2785) |
2 |
OB_001465 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
normal |
e1368 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trehalose |
5 |
mM |
|
|
increased |
68.40% |
45.3 |
26.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2786) |
3 |
OB_004387 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trehalose |
5 |
mM |
|
|
increased |
31.60% |
35.4 |
26.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2779) |
4 |
OB_004386 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trehalose |
1 |
mM |
|
|
increased |
24.16% |
33.4 |
26.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2778) |
5 |
OB_004388 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trehalose |
10 |
mM |
|
|
increased |
19.33% |
32.1 |
26.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2780) |
6 |
OB_004392 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trehalose |
5 |
mM |
|
|
increased |
11.63% |
24 |
21.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2794) |
7 |
OB_001473 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-7 |
Caenorhabditis elegans |
175237 |
unknown |
e1372 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trehalose |
5 |
mM |
|
|
none |
3.35% |
27.8 |
26.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2793) |
8 |
OB_001468 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
unknown |
e1370 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trehalose |
5 |
mM |
|
|
decreased |
-24.16% |
20.4 |
26.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2789) |
9 |
OB_001470 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trehalose |
5 |
mM |
|
|
decreased |
-27.51% |
19.5 |
26.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2790) |