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BrowseCompound: Alpha, beta-trehalose - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
| Compound Name | : | Alpha, beta-trehalose | ||||||||||||||||
| Species | : | Caenorhabditis elegans | ||||||||||||||||
| Ageing Relevance Analysis | : |
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| Ageing Factor Stable ID | : | AF_009083 | ||||||||||||||||
| Download | : | ![[xml icon]](/assets/images/general/xml.gif "xml") XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
| Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| # | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
| 1 | OB_004389 | Caenorhabditis elegans | N2 |
|
none | -0.74% | 26.7 | 26.9 | days | mean | 20 | ℃ | hermaphrodite | Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. | Honda et al. | 2010 | 20477758 | ![[DOI icon]](/assets/images/general/db_doi.gif) doi:10.1111/j.1474-9726.2010.00582.x |
![[Lifespan Observations Database icon]](/assets/images/general/db_lodb.gif) Lifespan Observations Database (ID: 2781) |
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Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Honda Y, Tanaka M, Honda S:
Trehalose extends longevity in the nematode Caenorhabditis elegans.
Aging Cell. 2010; 9: 558-69.![[PubMed icon]](/assets/images/general/db_pubmed.gif)
PubMed (ID: 20477758), doi:10.1111/j.1474-9726.2010.00582.x
MeSH Terms: Caenorhabditis elegans/drug effects; Caenorhabditis elegans/physiology; Longevity/drug effects; Trehalose/pharmacology