1 |
OB_004397 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
2.24 |
mg/kg/day |
|
|
increased |
21.15% |
1077 |
889 |
days |
median |
|
|
female |
Rapamycin feeding initiated at 9 months increased median and maximum life span of UM-HET3 male and female animals. |
Miller et al. |
2011 |
20974732 |
doi:10.1093/gerona/glq178 |
Lifespan Observations Database (ID: 3831) |
2 |
OB_004726 |
Saccharomyces cerevisiae |
BY4741 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
0.55 |
nM |
|
|
increased |
20.00% |
|
|
days |
median |
30 |
℃ |
mata |
Treatment of yeast cells with the specific TORC1 inhibitor rapamycin or caffeine releases Rim15 from TORC1-Sch9-mediated inhibition and consequently increases lifespan. |
Wanke et al. |
2008 |
18513215 |
doi:10.1111/j.1365-2958.2008.06292.x |
Lifespan Observations Database (ID: 895) |
3 |
OB_004399 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
2.24 |
mg/kg/day |
|
|
increased |
19.34% |
1006 |
843 |
days |
median |
|
|
female |
Rapamycin feeding initiated at 9 months increased median and maximum life span of UM-HET3 male and female animals. |
Miller et al. |
2011 |
20974732 |
doi:10.1093/gerona/glq178 |
Lifespan Observations Database (ID: 3833) |
4 |
OB_004409 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
2.24 |
mg/kg/day |
|
|
increased |
16.00% |
|
|
days |
mean |
|
|
female |
Rapamycin feeding initiated at 600 days of age significantly increased mean and maximum life span of UM-HET3 mice. |
Harrison et al. |
2009 |
19587680 |
doi:10.1038/nature08221 |
Lifespan Observations Database (ID: 3843) |
5 |
OB_004408 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
2.24 |
mg/kg/day |
|
|
increased |
15.00% |
|
|
days |
mean |
|
|
female |
Rapamycin feeding initiated at 600 days of age significantly increased mean and maximum life span of UM-HET3 mice. |
Harrison et al. |
2009 |
19587680 |
doi:10.1038/nature08221 |
Lifespan Observations Database (ID: 3842) |
6 |
OB_004413 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
2.24 |
mg/kg/day |
|
|
increased |
15.00% |
|
|
days |
mean |
|
|
male |
Rapamycin feeding initiated at 600 days of age significantly increased mean and maximum life span of UM-HET3 mice. |
Harrison et al. |
2009 |
19587680 |
doi:10.1038/nature08221 |
Lifespan Observations Database (ID: 3847) |
7 |
OB_004396 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
2.24 |
mg/kg/day |
|
|
increased |
13.85% |
888 |
780 |
days |
median |
|
|
male |
Rapamycin feeding initiated at 9 months increased median and maximum life span of UM-HET3 male and female animals. |
Miller et al. |
2011 |
20974732 |
doi:10.1093/gerona/glq178 |
Lifespan Observations Database (ID: 3830) |
8 |
OB_004725 |
Mus musculus |
C57BL/6 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
4 |
mg/kg every other day |
|
|
increased |
13.54% |
2.6 |
2.29 |
years |
median |
|
|
|
Age-matched 22- to 24-month-old male B6 mice were treated with vehicle or rapamycin (4 mg/kg body weight ip) every other day for 6 weeks. At 30 weeks after the first treatment with rapamycin, 80% of control animals were dead, while only 20% of the rapamycin treated animals were dead. |
Chen et al. |
2009 |
19934433 |
doi:10.1126/scisignal.2000559 |
Lifespan Observations Database (ID: 545) |
9 |
OB_004398 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
2.24 |
mg/kg/day |
|
|
increased |
13.13% |
1008 |
891 |
days |
median |
|
|
female |
Rapamycin feeding initiated at 9 months increased median and maximum life span of UM-HET3 male and female animals. |
Miller et al. |
2011 |
20974732 |
doi:10.1093/gerona/glq178 |
Lifespan Observations Database (ID: 3832) |
10 |
OB_004395 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
2.24 |
mg/kg/day |
|
|
increased |
9.52% |
932 |
851 |
days |
median |
|
|
male |
Rapamycin feeding initiated at 9 months increased median and maximum life span of UM-HET3 male and female animals. |
Miller et al. |
2011 |
20974732 |
doi:10.1093/gerona/glq178 |
Lifespan Observations Database (ID: 3829) |
11 |
OB_004412 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
2.24 |
mg/kg/day |
|
|
increased |
8.00% |
|
|
days |
mean |
|
|
male |
Rapamycin feeding initiated at 600 days of age significantly increased mean and maximum life span of UM-HET3 mice. |
Harrison et al. |
2009 |
19587680 |
doi:10.1038/nature08221 |
Lifespan Observations Database (ID: 3846) |
12 |
OB_004410 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
2.24 |
mg/kg/day |
|
|
increased |
7.00% |
|
|
days |
mean |
|
|
female |
Rapamycin feeding initiated at 600 days of age significantly increased mean and maximum life span of UM-HET3 mice. |
Harrison et al. |
2009 |
19587680 |
doi:10.1038/nature08221 |
Lifespan Observations Database (ID: 3844) |
13 |
OB_004394 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
2.24 |
mg/kg/day |
|
|
increased |
5.12% |
841 |
800 |
days |
median |
|
|
male |
Rapamycin feeding initiated at 9 months increased median and maximum life span of UM-HET3 male and female animals. |
Miller et al. |
2011 |
20974732 |
doi:10.1093/gerona/glq178 |
Lifespan Observations Database (ID: 3828) |
14 |
OB_004411 |
Mus musculus |
UM-HET3 |
|
Compound Name |
Quantity |
Quantity Unit |
Rapamycin |
2.24 |
mg/kg/day |
|
|
increased |
5.00% |
|
|
days |
mean |
|
|
male |
Rapamycin feeding initiated at 600 days of age significantly increased mean and maximum life span of UM-HET3 mice. |
Harrison et al. |
2009 |
19587680 |
doi:10.1038/nature08221 |
Lifespan Observations Database (ID: 3845) |