Compound: Simvastatin - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Simvastatin | ||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009087 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004404 | Mus musculus | UM-HET3 |
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none | days | median | female | Simvastatin feeding initiated at 10 months of age had no effect on life span of UM-HET3 male or female animals at either 12 mg/kg/day or 120 mg/kd/day . | Miller et al. | 2011 | 20974732 | doi:10.1093/gerona/glq178 | Lifespan Observations Database (ID: 3838) | |||||||||||||
2 | OB_004405 | Mus musculus | UM-HET3 |
|
none | days | median | male | Simvastatin feeding initiated at 10 months of age had no effect on life span of UM-HET3 male or female animals at either 12 mg/kg/day or 120 mg/kd/day . | Miller et al. | 2011 | 20974732 | doi:10.1093/gerona/glq178 | Lifespan Observations Database (ID: 3839) | |||||||||||||
3 | OB_004406 | Mus musculus | UM-HET3 |
|
none | days | median | male | Simvastatin feeding initiated at 10 months of age had no effect on life span of UM-HET3 male or female animals at either 12 mg/kg/day or 120 mg/kd/day . | Miller et al. | 2011 | 20974732 | doi:10.1093/gerona/glq178 | Lifespan Observations Database (ID: 3840) | |||||||||||||
4 | OB_004407 | Mus musculus | UM-HET3 |
|
none | days | median | female | Simvastatin feeding initiated at 10 months of age had no effect on life span of UM-HET3 male or female animals at either 12 mg/kg/day or 120 mg/kd/day . | Miller et al. | 2011 | 20974732 | doi:10.1093/gerona/glq178 | Lifespan Observations Database (ID: 3841) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R:
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
J Gerontol A Biol Sci Med Sci. 2011; 66: 191-201.
PubMed (ID: 20974732), PubMed Central (ID: PMC3021372), doi:10.1093/gerona/glq178
MeSH Terms: Longevity/drug effects; Simvastatin/administration & dosage; Sirolimus/administration & dosage; Stilbenes/administration & dosage