Compound: Phenformin - Caenorhabditis elegans, Mus musculus, Rattus norvegicus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Phenformin | ||||||||||||||||||||
Species | : | Caenorhabditis elegans, Mus musculus, Rattus norvegicus | ||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009088 | ||||||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004419 | Mus musculus | C3H/Sn |
|
increased | 28.37% | 810 | 631 | days | max | female | Female C3H/Sn mice were treated with phenformin (5 mg/mouse 5 treatments per week) starting at 3.5 months of age in 0.2 mL of drinking water until death. Mean and maximum life span were extended. | Anisimov et al. | 2003 | 14618027 | Lifespan Observations Database (ID: 3853) | |||||||||||
2 | OB_004695 | Caenorhabditis elegans | N2 |
|
increased | 26.38% | 24.53 | 19.41 | days | mean | 20 | ℃ | Phenformin at 4.5 mM increased lifespan of N2 by 26%. | Cabreiro et al. | 2013 | 23540700 | doi:10.1016/j.cell.2013.02.035 | Lifespan Observations Database (ID: 5379) | |||||||||
3 | OB_004418 | Mus musculus | C3H/Sn |
|
increased | 21.11% | 545 | 450 | days | mean | female | Female C3H/Sn mice were treated with phenformin (5 mg/mouse 5 treatments per week) starting at 3.5 months of age in 0.2 mL of drinking water until death. Mean and maximum life span were extended. | Anisimov et al. | 2003 | 14618027 | Lifespan Observations Database (ID: 3852) | |||||||||||
4 | OB_004694 | Caenorhabditis elegans | N2 |
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increased | 20.66% | 23.42 | 19.41 | days | mean | 20 | ℃ | Phenformin at 3 mM increased lifespan of N2 by 21%. | Cabreiro et al. | 2013 | 23540700 | doi:10.1016/j.cell.2013.02.035 | Lifespan Observations Database (ID: 5378) | |||||||||
5 | OB_004415 | Rattus norvegicus | LIO |
|
increased | 9.79% | 1009 | 919 | days | max | female | Female outbred LIO rats were treated with phenformin (5 mg/rat/day) starting at 3.5 months of age in 1.0 mL of drinking water until death. No change in mean life span was observed; however, maximum life span was extended. | Anisimov et al. | 2003 | 14618027 | Lifespan Observations Database (ID: 3849) | |||||||||||
6 | OB_004693 | Caenorhabditis elegans | N2 |
|
increased | 5.36% | 20.45 | 19.41 | days | mean | 20 | ℃ | Phenformin at 1.5 mM increased lifespan of N2 by 5%,. | Cabreiro et al. | 2013 | 23540700 | doi:10.1016/j.cell.2013.02.035 | Lifespan Observations Database (ID: 5377) | |||||||||
7 | OB_004414 | Rattus norvegicus | LIO |
|
none | 0.00% | 652 | 652 | days | mean | female | Female outbred LIO rats were treated with phenformin (5 mg/rat/day) starting at 3.5 months of age in 1.0 mL of drinking water until death. No change in mean life span was observed; however, maximum life span was extended. | Anisimov et al. | 2003 | 14618027 | Lifespan Observations Database (ID: 3848) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Anisimov VN, Semenchenko AV, Yashin AI:
Insulin and longevity: antidiabetic biguanides as geroprotectors.
Biogerontology. 2003; 4: 297-307.
PubMed (ID: 14618027)
MeSH Terms: Aging/drug effects; Buformin/pharmacology; Hypoglycemic Agents/pharmacology; Insulin/metabolism; Longevity/drug effects; Phenformin/pharmacology - Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D:
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Cell. 2013; 153: 228-39.
PubMed (ID: 23540700), doi:10.1016/j.cell.2013.02.035
MeSH Terms: Caenorhabditis elegans/drug effects; Caenorhabditis elegans/microbiology; Folic Acid/metabolism; Hypoglycemic Agents/pharmacology; Longevity/drug effects; Metformin/pharmacology; Methionine/metabolism