Compound: Buformin - Rattus norvegicus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Buformin | ||||||||||||||||
Species | : | Rattus norvegicus | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009089 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004416 | Rattus norvegicus | LIO |
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increased | 12.00% | 1036 | 925 | days | max | female | Female outbred LIO rats were treated with buformin (5 mg/rat/day) starting at 3.5 months of age in 1.0 mL of drinking water until death. No change in mean life span was observed; however, maximum life span was extended. | Anisimov et al. | 2003 | 14618027 | Lifespan Observations Database (ID: 3850) | |||||||||||
2 | OB_004417 | Rattus norvegicus | LIO |
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increased | 7.28% | 737 | 687 | days | mean | female | Female outbred LIO rats were treated with buformin (5 mg/rat/day) starting at 3.5 months of age in 1.0 mL of drinking water until death. No change in mean life span was observed; however, maximum life span was extended. | Anisimov et al. | 2003 | 14618027 | Lifespan Observations Database (ID: 3851) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Anisimov VN, Semenchenko AV, Yashin AI:
Insulin and longevity: antidiabetic biguanides as geroprotectors.
Biogerontology. 2003; 4: 297-307.
PubMed (ID: 14618027)
MeSH Terms: Aging/drug effects; Buformin/pharmacology; Hypoglycemic Agents/pharmacology; Insulin/metabolism; Longevity/drug effects; Phenformin/pharmacology