1 |
OB_004706 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
50 |
mM |
|
|
increased |
38.63% |
26.02 |
18.77 |
days |
mean |
20 |
℃ |
|
Lifespan of N2 cultured on multi-antibiotic resistant OP50-R26 increased by approximately 39% with treatment of Metformin (50 mM). |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5390) |
2 |
OB_004691 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
50 |
mM |
|
|
increased |
36.33% |
29.23 |
21.44 |
days |
mean |
20 |
℃ |
|
Metformin at 50 mM increased mean lifespan by 36%. |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5375) |
3 |
OB_004705 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
50 |
mM |
|
|
increased |
33.30% |
28.62 |
21.47 |
days |
mean |
20 |
℃ |
|
Lifespan of N2 cultured on OP50 pre-treated with 120 M carbenicillin increased by approximately 33% with treatment of Metformin (50 mM). |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5389) |
4 |
OB_004701 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
50 |
mM |
|
|
increased |
25.44% |
23.57 |
18.79 |
days |
mean |
20 |
℃ |
|
Metformin increased lifespan to a similar degree in the absence (25%) or presence of carbenicillin (24%). Thus, metformin does not increase lifespan by preventing bacterial proliferation. |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5385) |
5 |
OB_004702 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Carbenicillin |
4 |
mM |
Metformin |
50 |
mM |
|
|
increased |
23.67% |
29.15 |
23.57 |
days |
mean |
20 |
℃ |
|
Metformin increased lifespan to a similar degree in the absence (25%) or presence of carbenicillin (24%). Thus, metformin does not increase lifespan by preventing bacterial proliferation. |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5386) |
6 |
OB_004690 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
25 |
mM |
|
|
increased |
18.33% |
25.37 |
21.44 |
days |
mean |
20 |
℃ |
|
Metformin at 25 mM increased mean lifespan of N2 by 18%. |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5374) |
7 |
OB_004704 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
50 |
mM |
|
|
increased |
13.90% |
24.66 |
21.65 |
|
|
20 |
℃ |
|
Lifespan of N2 cultured on UV-irradiated OP50 was approximately 14% greater than live OP50, both treatments with Metformin (50 mM). |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5388) |
8 |
OB_004423 |
Mus musculus |
HER-2/neu |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
100 |
mg/kg 5 doses/week |
|
|
increased |
13.13% |
336 |
297 |
days |
max |
|
|
female |
The chronic treatment of female transgenic HER-2/neu mice with metformin (100 mg/kg in drinking water) slightly decreased the food consumption but failed in reducing the body weight or temperature, slowed down the age-related rise in blood glucose and triglycerides level, as well as the age-related switch-off of estrous function, prolonged the mean life span by 8% (p!0.05), the mean life span of last 10% survivors by 13.1%, and the maximum life span by 1 month in comparison with control mice. |
Anisimov et al. |
2005 |
16125352 |
doi:10.1016/j.exger.2005.07.007 |
Lifespan Observations Database (ID: 3857) |
9 |
OB_004703 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
50 |
mM |
|
Other Ageing Factor Name |
Additional Information |
Diet |
Cultured on Bacillus subtilis. |
|
increased |
9.44% |
29.32 |
26.79 |
days |
mean |
20 |
℃ |
|
Metformin (50 mM) increased lifespan of worms cultured on B. subtilis by 9%. |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5387) |
10 |
OB_004696 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
25 |
mM |
|
|
increased |
8.03% |
25.01 |
23.15 |
days |
mean |
20 |
℃ |
|
Metformin increased mean lifespan by 8% when administered from middle age onward, but only at 25 mM. |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5380) |
11 |
OB_004424 |
Mus musculus |
HER-2/neu |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
100 |
mg/kg 5 doses/week |
|
|
increased |
7.95% |
285 |
264 |
days |
mean |
|
|
female |
The chronic treatment of female transgenic HER-2/neu mice with metformin (100 mg/kg in drinking water) slightly decreased the food consumption but failed in reducing the body weight or temperature, slowed down the age-related rise in blood glucose and triglycerides level, as well as the age-related switch-off of estrous function, prolonged the mean life span by 8% (p!0.05), the mean life span of last 10% survivors by 13.1%, and the maximum life span by 1 month in comparison with control mice. |
Anisimov et al. |
2005 |
16125352 |
doi:10.1016/j.exger.2005.07.007 |
Lifespan Observations Database (ID: 3858) |
12 |
OB_004420 |
Mus musculus |
HER-2/neu |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
100 |
mg/kg 5 doses/week |
|
|
increased |
6.67% |
304 |
285 |
days |
mean |
|
|
female |
Metformin (0.5 mg/ml in drinking water) increased mean life span by 8% and MAC latency by 13.2% (p < 0.05) in HER2/neu mice. The treatment with melatonin alone (2 mg/L in drinking water during the night time) or combined treatment with metformin (0.5 mg/ ml in drinking water during the day time) + melatonin (2 mg/L in drinking water during the night time) did not influence mammary carcinogenesis in the mice. |
Anisimov et al. |
2010 |
20016287 |
|
Lifespan Observations Database (ID: 3854) |
13 |
OB_004692 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
100 |
mM |
|
|
none |
3.40% |
22.17 |
21.44 |
days |
mean |
20 |
℃ |
|
Metformin at 100 mM increased mean lifespan by 3%. |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5376) |
14 |
OB_004425 |
Rattus norvegicus |
Fischer-344 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
300 |
mg/kg/day |
|
|
none |
2.27% |
814.5 |
796.4 |
|
|
|
|
male |
Although CR significantly extended early life span (25th quantile) of Fischer-344 rats, metformin supplementation (300 mg/kg/day) did not significantly increase life span at any quantile (25th, 50th, 75th, or 90th), overall or maximum life span (p > .05) compared with control. |
Smith et al. |
2010 |
20304770 |
doi:10.1093/gerona/glq033 |
Lifespan Observations Database (ID: 3859) |
15 |
OB_004697 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
50 |
mM |
|
|
none |
1.51% |
23.5 |
23.15 |
days |
mean |
20 |
℃ |
|
Metformin increased mean lifespan by 8% when administered from middle age onward, but only at 25 mM. |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5381) |
16 |
OB_004699 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
2 |
mM |
|
Other Ageing Factor Name |
Additional Information |
Diet |
N2 cultured on axenic plates. |
|
none |
-2.14% |
17.8 |
18.19 |
days |
mean |
20 |
℃ |
|
Lifespan of N2 cultured on axenic medium caused an increase in worm lifespan, typical of DR. Under these conditions, metformin did not in- crease worm lifespan, but instead markedly reduced it. |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5383) |
17 |
OB_004700 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
10 |
mM |
|
Other Ageing Factor Name |
Additional Information |
Diet |
N2 cultured on axenic plates. |
|
decreased |
-6.27% |
17.05 |
18.19 |
days |
mean |
20 |
℃ |
|
Lifespan of N2 cultured on axenic medium caused an increase in worm lifespan, typical of DR. Under these conditions, metformin did not increase worm lifespan, but instead markedly reduced it. 10 mM metformin decreased lifespan by 6%. |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5384) |
18 |
OB_004421 |
Mus musculus |
HER-2/neu |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
100 |
mg/kg 5 doses/week |
|
|
decreased |
-11.11% |
352 |
396 |
days |
max |
|
|
female |
Metformin (0.5 mg/ml in drinking water) increased mean life span by 8% and MAC latency by 13.2% (p < 0.05) in HER2/neu mice. The treatment with melatonin alone (2 mg/L in drinking water during the night time) or combined treatment with metformin (0.5 mg/ ml in drinking water during the day time) + melatonin (2 mg/L in drinking water during the night time) did not influence mammary carcinogenesis in the mice. |
Anisimov et al. |
2010 |
20016287 |
|
Lifespan Observations Database (ID: 3855) |
19 |
OB_004422 |
Mus musculus |
HER-2/neu |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
100 |
mg/kg 5 doses/week |
|
|
decreased |
-11.11% |
352 |
396 |
days |
max |
|
|
female |
Metformin (0.5 mg/ml in drinking water) increased mean life span by 8% and MAC latency by 13.2% (p < 0.05) in HER2/neu mice. The treatment with melatonin alone (2 mg/L in drinking water during the night time) or combined treatment with metformin (0.5 mg/ ml in drinking water during the day time) + melatonin (2 mg/L in drinking water during the night time) did not influence mammary carcinogenesis in the mice. |
Anisimov et al. |
2010 |
20016287 |
|
Lifespan Observations Database (ID: 3856) |
20 |
OB_004698 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Metformin |
100 |
mM |
|
|
decreased |
-15.98% |
19.45 |
23.15 |
days |
mean |
20 |
℃ |
|
Metformin (100 mM) decreased mean lifespan by 16% when administered from middle age onward. |
Cabreiro et al. |
2013 |
23540700 |
doi:10.1016/j.cell.2013.02.035 |
Lifespan Observations Database (ID: 5382) |