1 |
OB_002607 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
|
increased |
125.15% |
37.6 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3893) |
2 |
OB_004429 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
Other Ageing Factor Name |
Additional Information |
B. subtilis food |
Feeding C. elegans B. subtilis instead of E. coli. |
|
increased |
91.02% |
31.9 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3874) |
3 |
OB_002622 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad465 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
|
increased |
71.26% |
28.6 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3906) |
4 |
OB_002604 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
unc-31 |
Caenorhabditis elegans |
178233 |
unknown |
e928 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
|
increased |
69.46% |
28.3 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3890) |
5 |
OB_002609 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
unc-64 |
Caenorhabditis elegans |
176743 |
loss of function |
e246 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
|
increased |
68.26% |
28.1 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3895) |
6 |
OB_004431 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
Other Ageing Factor Name |
Additional Information |
UV killed food |
Feeding C. elegans UV killed E. coli |
|
increased |
68.26% |
28.1 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3877) |
7 |
OB_004505 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
0.2 |
mg |
|
|
increased |
66.67% |
12.5 |
7.5 |
days |
mean |
25 |
℃ |
|
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with liposomes containing 0.2 mg trimethadione was 66% greater than controls. |
Shibamura et al. |
2009 |
19580823 |
doi:10.1016/j.mad.2009.06.008 |
Lifespan Observations Database (ID: 4657) |
8 |
OB_004506 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
0.4 |
mg |
|
|
increased |
66.67% |
12.5 |
7.5 |
days |
mean |
25 |
℃ |
|
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with liposomes containing 0.4 mg trimethadione was 66% greater than controls. |
Shibamura et al. |
2009 |
19580823 |
doi:10.1016/j.mad.2009.06.008 |
Lifespan Observations Database (ID: 4658) |
9 |
OB_004507 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
0.6 |
mg |
|
|
increased |
66.67% |
12.5 |
7.5 |
days |
mean |
25 |
℃ |
|
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with liposomes containing 0.6 mg trimethadione was 66% greater than controls. |
Shibamura et al. |
2009 |
19580823 |
doi:10.1016/j.mad.2009.06.008 |
Lifespan Observations Database (ID: 4659) |
10 |
OB_002617 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
tax-4 |
Caenorhabditis elegans |
176297 |
unknown |
p678 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
|
increased |
64.07% |
27.4 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3901) |
11 |
OB_004441 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
28 |
mM |
Valproic acid |
6 |
mM |
|
|
increased |
61.11% |
26.1 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3918) |
12 |
OB_002613 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aex-3 |
Caenorhabditis elegans |
180420 |
unknown |
ad418 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
|
increased |
55.69% |
26 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3899) |
13 |
OB_004432 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
|
increased |
47.31% |
24.6 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3878) |
14 |
OB_004440 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
28 |
mM |
|
|
increased |
45.06% |
23.5 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3917) |
15 |
OB_002619 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
osm-3 |
Caenorhabditis elegans |
177141 |
unknown |
p802 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
2 |
mg/ml |
|
|
increased |
32.34% |
22.1 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3903) |
16 |
OB_002600 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
|
none |
4.19% |
17.4 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3887) |
17 |
OB_002594 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
|
none |
0.00% |
16.7 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3881) |
18 |
OB_002599 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
2 |
mg/ml |
|
|
none |
0.00% |
16.7 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3886) |
19 |
OB_004508 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
40 |
mg |
|
|
none |
0.00% |
7.5 |
7.5 |
days |
mean |
25 |
℃ |
|
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented without liposomes, NGM containing 40 mg trimethadione was not significantly different than controls. |
Shibamura et al. |
2009 |
19580823 |
doi:10.1016/j.mad.2009.06.008 |
Lifespan Observations Database (ID: 4660) |