Compound: 3,3-diethyl-2-pyrrolidinone - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | 3,3-diethyl-2-pyrrolidinone | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009093 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004433 | Caenorhabditis elegans | N2 |
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increased | 30.54% | 21.8 | 16.7 | days | mean | 20 | ℃ | hermaphrodite | The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. | Evason et al. | 2005 | 15653505 | doi:10.1126/science.1105299 | Lifespan Observations Database (ID: 3879) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Evason K, Huang C, Yamben I, Covey DF, Kornfeld K:
Anticonvulsant medications extend worm life-span.
Science. 2005; 307: 258-62.
PubMed (ID: 15653505), doi:10.1126/science.1105299
MeSH Terms: Aging/drug effects; Anticonvulsants/pharmacology; Caenorhabditis elegans/drug effects; Ethosuximide/pharmacology; Lactams/pharmacology; Longevity/drug effects; Trimethadione/pharmacology