Compound: Cyclosporin A - Podospora anserina
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name |
: |
Cyclosporin A |
Species |
: |
Podospora anserina |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
none |
1 |
no (Exp. Analysis) |
Lifespan Observations Database |
Total |
1 |
|
|
|
Ageing Factor Stable ID |
: |
AF_009098 |
Download |
: |
XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_004447 |
Podospora anserina |
s |
|
Compound Name |
Quantity |
Quantity Unit |
Cyclosporin A |
0.02 |
micrograms/ml |
|
|
none |
3.60% |
11.5 |
11.1 |
days |
mean |
|
|
|
Treatment of the P. anserina wildtype with low concentrations of the cyclophilin inhibitor cyclosporin A (CSA) extends lifespan. Transgenic strains overexpressing PaCypD are characterized by reduced stress tolerance, suffer from pronounced mitochondrial dysfunction and are characterized by accelerated aging and induction of cell death. Treatment with CSA leads to correction of mitochondrial function and lifespan to that of the wild-type. In contrast, PaCypD deletion strains have a normal life span, are not affected by CSA within the investigated concentration range and show increased resistance against inducers of oxidative stress and cell death. |
Brust et al. |
2010 |
20626725 |
doi:10.1111/j.1474-9726.2010.00609.x |
Lifespan Observations Database (ID: 3968) |
2 |
OB_004449 |
Podospora anserina |
s |
|
Compound Name |
Quantity |
Quantity Unit |
Cyclosporin A |
0.1 |
micrograms/ml |
|
|
none |
1.80% |
11.3 |
11.1 |
days |
mean |
|
|
|
Treatment of the P. anserina wildtype with low concentrations of the cyclophilin inhibitor cyclosporin A (CSA) extends lifespan. Transgenic strains overexpressing PaCypD are characterized by reduced stress tolerance, suffer from pronounced mitochondrial dysfunction and are characterized by accelerated aging and induction of cell death. Treatment with CSA leads to correction of mitochondrial function and lifespan to that of the wild-type. In contrast, PaCypD deletion strains have a normal life span, are not affected by CSA within the investigated concentration range and show increased resistance against inducers of oxidative stress and cell death. |
Brust et al. |
2010 |
20626725 |
doi:10.1111/j.1474-9726.2010.00609.x |
Lifespan Observations Database (ID: 3970) |
3 |
OB_004448 |
Podospora anserina |
s |
|
Compound Name |
Quantity |
Quantity Unit |
Cyclosporin A |
0.04 |
micrograms/ml |
|
|
none |
0.00% |
11.1 |
11.1 |
days |
mean |
|
|
|
Treatment of the P. anserina wildtype with low concentrations of the cyclophilin inhibitor cyclosporin A (CSA) extends lifespan. Transgenic strains overexpressing PaCypD are characterized by reduced stress tolerance, suffer from pronounced mitochondrial dysfunction and are characterized by accelerated aging and induction of cell death. Treatment with CSA leads to correction of mitochondrial function and lifespan to that of the wild-type. In contrast, PaCypD deletion strains have a normal life span, are not affected by CSA within the investigated concentration range and show increased resistance against inducers of oxidative stress and cell death. |
Brust et al. |
2010 |
20626725 |
doi:10.1111/j.1474-9726.2010.00609.x |
Lifespan Observations Database (ID: 3969) |
Homology Analysis
no homology analysis observation available
Sources
Ageing-related Data Sources
Additional Data Sources