Compound: FCCP - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | FCCP | ||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009099 | ||||||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||||||||
1 | OB_004450 | Caenorhabditis elegans | N2 |
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increased | 17.30% | 21.7 | 18.5 | days | mean | 20 | ℃ | hermaphrodite | Knock-down of the Caenorhabditis elegans apurinic/apyrimidinic endonuclease 1 (APE1) ortholog exo-3 reduced life span. Treatment of exo-3 animals with the mitochondrial uncoupler FCCP or knock-down of cep-1 increased life span. | Schlotterer et al. | 2010 | 20346071 | doi:10.1111/j.1474-9726.2010.00572.x | Lifespan Observations Database (ID: 3994) | ||||||||||||||||||||||
2 | OB_002700 | Caenorhabditis elegans | N2 |
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none | -3.78% | 17.8 | 18.5 | days | mean | 20 | ℃ | hermaphrodite | Knock-down of the Caenorhabditis elegans apurinic/apyrimidinic endonuclease 1 (APE1) ortholog exo-3 reduced life span. Treatment of exo-3 animals with the mitochondrial uncoupler FCCP or knock-down of cep-1 increased life span. | Schlotterer et al. | 2010 | 20346071 | doi:10.1111/j.1474-9726.2010.00572.x | Lifespan Observations Database (ID: 3995) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Schlotterer A, Hamann A, Kukudov G, Ibrahim Y, Heckmann B, Bozorgmehr F, Pfeiffer M, Hutter H, Stern D, Du X, Brownlee M, Bierhaus A, Nawroth P, Morcos M:
Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.
Aging Cell. 2010; 9: 420-32.
PubMed (ID: 20346071), doi:10.1111/j.1474-9726.2010.00572.x
MeSH Terms: Aging; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/metabolism; Thioredoxins/metabolism; Tumor Suppressor Protein p53/metabolism