Compound: 2,4-dinitrophenol - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | 2,4-dinitrophenol | ||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009101 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004453 | Mus musculus | Swiss |
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increased | 7.08% | 769.7 | 718.8 | days | mean | female | Swiss mice treated with 2,4-dinitrophenol at 1 mg/L in drinking water starting at 18 weeks of age showed a significant increase in mean life span. | Caldeira da Silva et al. | 2008 | 18505478 | doi:10.1111/j.1474-9726.2008.00407.x | Lifespan Observations Database (ID: 4148) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Caldeira da Silva CC, Cerqueira FM, Barbosa LF, Medeiros MH, Kowaltowski AJ:
Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity.
Aging Cell. 2008; 7: 552-60.
PubMed (ID: 18505478), doi:10.1111/j.1474-9726.2008.00407.x
MeSH Terms: 2,4-Dinitrophenol/pharmacology; Energy Metabolism/drug effects; Longevity/drug effects; Mitochondria/drug effects; Mitochondria/metabolism; Uncoupling Agents/pharmacology