1 |
OB_003225 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-3 |
Caenorhabditis elegans |
181748 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
200 |
mM |
|
|
increased |
140.00% |
600 |
250 |
|
mean |
25 |
℃ |
|
In an acute survival test using 200 mM paraquat solution, sod-1 worms were hypersensitive to paraquat, whereas, surprisingly, sod-3 or sod-4 worms actually had a reduced sensitivity to paraquat. Mutational inactivation of other isoforms of sod had no effect on sensitivity to paraquat in this acute assay. |
Yen et al. |
2009 |
19059428 |
doi:10.1016/j.mad.2008.11.003 |
Lifespan Observations Database (ID: 4634) |
2 |
OB_004584 |
Caenorhabditis elegans |
clk-1(qm30) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
81.25% |
58 |
32 |
days |
max |
20 |
℃ |
|
Treatment of 0.1 mM paraquat increased maximum lifespan of clk-1(qm30) mutant worms by approximately 80% relative to mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5117) |
3 |
OB_004585 |
Caenorhabditis elegans |
clk-1(qm30) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
76.19% |
37 |
21 |
days |
mean |
20 |
℃ |
|
Treatment of 0.1 mM paraquat increased mean lifespan of clk-1(qm30) mutant worms by approximately 76% relative to mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5118) |
4 |
OB_004600 |
Caenorhabditis elegans |
hsf-1(y441) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
68.18% |
37 |
22 |
days |
max |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased maximum lifespan of hsf-1(y441) mutant worms by approximately 68% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5133) |
5 |
OB_004594 |
Caenorhabditis elegans |
jnk-1(gk7) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
60.22% |
29 |
18.1 |
days |
mean |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased mean lifespan of jnk-1(gk7) mutant worms by approximately 60% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5127) |
6 |
OB_004578 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
57.61% |
29 |
18.4 |
days |
mean |
20 |
℃ |
|
Treatment of 0.1 mM paraquat increased mean lifespan of N2 worms by approximately 58% relative to N2 lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5111) |
7 |
OB_004595 |
Caenorhabditis elegans |
jnk-1(gk7) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
56.00% |
39 |
25 |
days |
max |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased maximum lifespan of jnk-1(gk7) mutant worms by approximately 56% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5128) |
8 |
OB_004601 |
Caenorhabditis elegans |
hsf-1(y441) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
51.01% |
22.5 |
14.9 |
days |
mean |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased mean lifespan of hsf-1(y441) mutant worms by approximately 51% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5134) |
9 |
OB_004579 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
48.28% |
43 |
29 |
days |
max |
20 |
℃ |
|
Treatment of 0.1 mM paraquat increased maximum lifespan of N2 worms by approximately 48% relative to N2 lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5112) |
10 |
OB_003224 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-4 |
Caenorhabditis elegans |
176336 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
200 |
mM |
|
|
increased |
36.00% |
340 |
250 |
|
mean |
25 |
℃ |
|
In an acute survival test using 200 mM paraquat solution, sod-1 worms were hypersensitive to paraquat, whereas, surprisingly, sod-3 or sod-4 worms actually had a reduced sensitivity to paraquat. Mutational inactivation of other isoforms of sod had no effect on sensitivity to paraquat in this acute assay. |
Yen et al. |
2009 |
19059428 |
doi:10.1016/j.mad.2008.11.003 |
Lifespan Observations Database (ID: 4633) |
11 |
OB_004603 |
Caenorhabditis elegans |
hif-1(ia4) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
35.48% |
42 |
31 |
days |
max |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased maximum lifespan of hif-1(ia4) mutant worms by approximately 35% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5136) |
12 |
OB_004590 |
Caenorhabditis elegans |
daf-16(mu86) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
35.33% |
22.6 |
16.7 |
days |
mean |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased mean lifespan of daf-16(mu86) mutant worms by approximately 35% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5123) |
13 |
OB_004589 |
Caenorhabditis elegans |
eat-2(ad1116) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
34.48% |
39 |
29 |
days |
mean |
20 |
℃ |
|
Treatment of 0.1 mM paraquat increased mean lifespan of eat-2(ad1116) mutant worms by approximately 34% relative to mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5122) |
14 |
OB_004597 |
Caenorhabditis elegans |
wwp-1(ok1102) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
33.79% |
29.3 |
21.9 |
days |
mean |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased mean lifespan of wwp-1(ok1102) mutant worms by approximately 34% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5130) |
15 |
OB_004591 |
Caenorhabditis elegans |
daf-16(mu86) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
33.33% |
28 |
21 |
days |
max |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased maximum lifespan of daf-16(mu86) mutant worms by approximately 38% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5124) |
16 |
OB_004596 |
Caenorhabditis elegans |
wwp-1(ok1102) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
32.14% |
37 |
28 |
days |
max |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased maximum lifespan of wwp-1(ok1102) mutant worms by approximately 32% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5129) |
17 |
OB_004588 |
Caenorhabditis elegans |
eat-2(ad1116) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
31.82% |
58 |
44 |
days |
max |
20 |
℃ |
|
Treatment of 0.1 mM paraquat increased maximum lifespan of eat-2(ad1116) mutant worms by approximately 32% relative to mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5121) |
18 |
OB_004592 |
Caenorhabditis elegans |
aak-2(ok524) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
30.43% |
30 |
23 |
days |
max |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased maximum lifespan of aak-2(ok524) mutant worms by approximately 30% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5125) |
19 |
OB_004598 |
Caenorhabditis elegans |
skn-1(zu67) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
29.55% |
22.8 |
17.6 |
days |
mean |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased mean lifespan of skn-1(zu67) mutant worms by approximately 30% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5131) |
20 |
OB_004593 |
Caenorhabditis elegans |
aak-2(ok524) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
29.48% |
22.4 |
17.3 |
days |
mean |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased mean lifespan of aak-2(ok524) mutant worms by approximately 30% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5126) |
21 |
OB_004602 |
Caenorhabditis elegans |
hif-1(ia4) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
22.65% |
28.7 |
23.4 |
days |
mean |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased mean lifespan of hif-1(ia4) mutant worms by approximately 23% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5135) |
22 |
OB_004599 |
Caenorhabditis elegans |
skn-1(zu67) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
13.64% |
25 |
22 |
days |
max |
20 |
℃ |
|
Treatment with 0.1 mM paraquat increased maximum lifespan of skn-1(zu67) mutant worms by approximately 13% relative to normal mutant lifespan. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5132) |
23 |
OB_004587 |
Caenorhabditis elegans |
daf-2(e1370) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
10.45% |
74 |
67 |
days |
max |
20 |
℃ |
|
Treatment of 0.1 mM paraquat increased maximum lifespan of daf-2(e1370) mutant worms by approximately 10% relative to mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5120) |
24 |
OB_004580 |
Caenorhabditis elegans |
nuo-6(qm200) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
10.20% |
54 |
49 |
days |
max |
20 |
℃ |
|
Treatment of 0.1 mM paraquat increased maximum lifespan of nuo-6(qm200) worms by approximately 10% relative to nuo-6(qm200) mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5113) |
25 |
OB_004581 |
Caenorhabditis elegans |
nuo-6(qm200) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
9.09% |
36 |
33 |
days |
mean |
20 |
℃ |
|
Treatment of 0.1 mM paraquat increased mean lifespan of nuo-6(qm200) worms by approximately 9% relative to nuo-6(qm200) mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5114) |
26 |
OB_004586 |
Caenorhabditis elegans |
daf-2(e1370) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
increased |
9.09% |
48 |
44 |
days |
mean |
20 |
℃ |
|
Treatment of 0.1 mM paraquat increased mean lifespan of daf-2(e1370) mutant worms by approximately 9% relative to mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5119) |
27 |
OB_003227 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-2 |
Caenorhabditis elegans |
172632 |
deletion / null |
ok1030 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
200 |
mM |
|
|
none |
4.00% |
260 |
250 |
|
mean |
25 |
℃ |
|
In an acute survival test using 200 mM paraquat solution, sod-1 worms were hypersensitive to paraquat, whereas, surprisingly, sod-3 or sod-4 worms actually had a reduced sensitivity to paraquat. Mutational inactivation of other isoforms of sod had no effect on sensitivity to paraquat in this acute assay. |
Yen et al. |
2009 |
19059428 |
doi:10.1016/j.mad.2008.11.003 |
Lifespan Observations Database (ID: 4636) |
28 |
OB_004582 |
Caenorhabditis elegans |
isp-1(qm150) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
none |
3.24% |
35 |
33.9 |
days |
mean |
20 |
℃ |
|
Treatment of 0.1 mM paraquat increased mean lifespan of isp-1(qm150) mutant worms by approximately 3% relative to mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5115) |
29 |
OB_003223 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-5 |
Caenorhabditis elegans |
173776 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
200 |
mM |
|
|
none |
-4.00% |
240 |
250 |
|
mean |
25 |
℃ |
|
In an acute survival test using 200 mM paraquat solution, sod-1 worms were hypersensitive to paraquat, whereas, surprisingly, sod-3 or sod-4 worms actually had a reduced sensitivity to paraquat. Mutational inactivation of other isoforms of sod had no effect on sensitivity to paraquat in this acute assay. |
Yen et al. |
2009 |
19059428 |
doi:10.1016/j.mad.2008.11.003 |
Lifespan Observations Database (ID: 4632) |
30 |
OB_004583 |
Caenorhabditis elegans |
isp-1(qm150) |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
0.1 |
mM |
|
|
decreased |
-5.66% |
50 |
53 |
days |
max |
20 |
℃ |
|
Treatment of 0.1 mM paraquat decreased maximum lifespan of isp-1(qm150) mutant worms by approximately 5% relative to mutant lifespan under normal conditions. |
Yang et al. |
2010 |
21151885 |
doi:10.1371/journal.pbio.1000556 |
Lifespan Observations Database (ID: 5116) |
31 |
OB_003190 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
gst-10 |
Caenorhabditis elegans |
178725 |
RNAi knockdown |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
100 |
mM |
|
|
decreased |
-11.36% |
23.4 |
26.4 |
|
mean |
20 |
℃ |
hermaphrodite |
Except in N2, RNAi-mediated inhibition of CeGSTP2-2 expression led to an increased susceptibility to 4-HNE, to heat shock and to paraquat toxicity. RNAi knockdown had no significant effect under conditions of paraquat exposure. |
Ayyadevara et al. |
2005 |
16300482 |
doi:10.1111/j.1474-9726.2005.00172.x |
Lifespan Observations Database (ID: 4602) |
32 |
OB_003226 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-2 |
Caenorhabditis elegans |
172632 |
deletion / null |
gk257 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
200 |
mM |
|
|
decreased |
-12.00% |
220 |
250 |
|
mean |
25 |
℃ |
|
In an acute survival test using 200 mM paraquat solution, sod-1 worms were hypersensitive to paraquat, whereas, surprisingly, sod-3 or sod-4 worms actually had a reduced sensitivity to paraquat. Mutational inactivation of other isoforms of sod had no effect on sensitivity to paraquat in this acute assay. |
Yen et al. |
2009 |
19059428 |
doi:10.1016/j.mad.2008.11.003 |
Lifespan Observations Database (ID: 4635) |
33 |
OB_003189 |
Caenorhabditis elegans |
daf-2(e1370) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
gst-10 |
Caenorhabditis elegans |
178725 |
RNAi knockdown |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
100 |
mM |
|
|
decreased |
-13.05% |
33.3 |
38.3 |
|
mean |
20 |
℃ |
hermaphrodite |
RNAi-mediated inhibition of CeGSTP2-2 expression led to an increased susceptibility to 4-HNE, to heat shock and to paraquat toxicity. RNAi knockdown reduced lifespan by approximately 13%. |
Ayyadevara et al. |
2005 |
16300482 |
doi:10.1111/j.1474-9726.2005.00172.x |
Lifespan Observations Database (ID: 4601) |
34 |
OB_003228 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-1 |
Caenorhabditis elegans |
174141 |
deletion / null |
tm783 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
200 |
mM |
|
|
decreased |
-40.00% |
150 |
250 |
|
mean |
25 |
℃ |
|
In an acute survival test using 200 mM paraquat solution, sod-1 worms were hypersensitive to paraquat, whereas, surprisingly, sod-3 or sod-4 worms actually had a reduced sensitivity to paraquat. |
Yen et al. |
2009 |
19059428 |
doi:10.1016/j.mad.2008.11.003 |
Lifespan Observations Database (ID: 4637) |
35 |
OB_003229 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sod-1 |
Caenorhabditis elegans |
174141 |
deletion / null |
tm776 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Paraquat |
200 |
mM |
|
|
decreased |
-42.00% |
145 |
250 |
|
mean |
25 |
℃ |
|
In an acute survival test using 200 mM paraquat solution, sod-1 worms were hypersensitive to paraquat, whereas, surprisingly, sod-3 or sod-4 worms actually had a reduced sensitivity to paraquat. |
Yen et al. |
2009 |
19059428 |
doi:10.1016/j.mad.2008.11.003 |
Lifespan Observations Database (ID: 4638) |