Compound: 4-HNE - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | 4-HNE | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009111 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||||||||
1 | OB_003193 | Caenorhabditis elegans | daf-2(e1370) |
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decreased | -9.35% | 5.33 | 5.88 | mean | 20 | ℃ | hermaphrodite | RNAi-mediated inhibition of CeGSTP2-2 expression led to an increased susceptibility to 4-HNE, to heat shock and to paraquat toxicity. RNAi knockdown reduced daf-2(e1370) lifespan approximately 10% with exposure to 4-HNE. | Ayyadevara et al. | 2005 | 16300482 | doi:10.1111/j.1474-9726.2005.00172.x | Lifespan Observations Database (ID: 4605) | ||||||||||||||||||||||
2 | OB_003194 | Caenorhabditis elegans | daf-2(e1370) |
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decreased | -12.71% | 3.71 | 4.25 | mean | 20 | ℃ | hermaphrodite | RNAi-mediated inhibition of CeGSTP2-2 expression led to an increased susceptibility to 4-HNE, to heat shock and to paraquat toxicity. RNAi knockdown reduced N2 lifespan approximately 13% with exposure to 4-HNE. | Ayyadevara et al. | 2005 | 16300482 | doi:10.1111/j.1474-9726.2005.00172.x | Lifespan Observations Database (ID: 4606) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Ayyadevara S, Dandapat A, Singh SP, Benes H, Zimniak L, Shmookler Reis RJ, Zimniak P:
Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2.
Aging Cell. 2005; 4: 299-307.
PubMed (ID: 16300482), doi:10.1111/j.1474-9726.2005.00172.x
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/enzymology; Glutathione Transferase/metabolism; Longevity/genetics; Oxidative Stress/genetics; Receptor, Insulin/genetics