Compound: Ascorbic acid - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name |
: |
Ascorbic acid |
Species |
: |
Caenorhabditis elegans |
Ageing Relevance Analysis |
: |
|
Ageing Factor Stable ID |
: |
AF_009112 |
Download |
: |
XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_004493 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascorbic acid |
60 |
mg |
|
|
increased |
66.67% |
12.5 |
7.5 |
days |
mean |
25 |
℃ |
|
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with 25 ml of liposomes containing 60 mg ascorbic acid (VC) was 66% greater than control. |
Shibamura et al. |
2009 |
19580823 |
doi:10.1016/j.mad.2009.06.008 |
Lifespan Observations Database (ID: 4645) |
2 |
OB_004494 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascorbic acid |
120 |
mg |
|
|
increased |
66.67% |
12.5 |
7.5 |
days |
mean |
25 |
℃ |
|
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with 120 ml of liposomes containing 60 mg ascorbic acid (VC) was 66% greater than control. |
Shibamura et al. |
2009 |
19580823 |
doi:10.1016/j.mad.2009.06.008 |
Lifespan Observations Database (ID: 4646) |
3 |
OB_004495 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascorbic acid |
240 |
mg |
|
|
increased |
46.67% |
11 |
7.5 |
days |
mean |
25 |
℃ |
|
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with 240 ml of liposomes containing 60 mg ascorbic acid (VC) was 45% greater than control. |
Shibamura et al. |
2009 |
19580823 |
doi:10.1016/j.mad.2009.06.008 |
Lifespan Observations Database (ID: 4647) |
4 |
OB_004500 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascorbic acid |
120 |
micrograms |
|
|
none |
0.00% |
7.5 |
7.5 |
days |
mean |
25 |
℃ |
|
Using liposomes, oral administration of hydrophilic antioxidants (ascorbic acid, N-acetyl-cysteine, reduced glutathione, and thioproline) prolonged the lifespan of the nematodes, whereas the conventional method of delivery showed neither fluorescence nor longevity effects. Survival of nematodes supplemented with NGM (without liposomes) containing 120 micrograms ascorbic acid was not significantly different than control. |
Shibamura et al. |
2009 |
19580823 |
doi:10.1016/j.mad.2009.06.008 |
Lifespan Observations Database (ID: 4652) |
Homology Analysis
no homology analysis observation available
Sources
Ageing-related Data Sources
Additional Data Sources