Compound: FUdR - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | FUdR | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009114 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||||||||
1 | OB_003289 | Caenorhabditis elegans | N2 |
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increased | 13.04% | 18.2 | 16.1 | days | mean | 25 | ℃ | FUdR treated worms show that the tub-1(ok1972) mutant has a 13% extended mean lifespan compared to N2 animals. The prolonged longevity of tub-1 worms is not observed when nematode lifespan is recorded in the absence of FUdR. | Aitlhadj et al. | 2010 | 20236608 | doi:10.1016/j.mad.2010.03.002 | Lifespan Observations Database (ID: 4710) | ||||||||||||||||||||||
2 | OB_003286 | Caenorhabditis elegans | N2 |
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increased | 12.50% | 18 | 16 | days | median | 25 | ℃ | FUdR treated worms show that the tub-1(nr2004) mutant has a 12% extended median lifespan compared to N2 animals. The prolonged longevity of tub-1 worms is not observed when nematode lifespan is recorded in the absence of FUdR. | Aitlhadj et al. | 2010 | 20236608 | doi:10.1016/j.mad.2010.03.002 | Lifespan Observations Database (ID: 4708) | ||||||||||||||||||||||
3 | OB_003287 | Caenorhabditis elegans | N2 |
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increased | 12.42% | 18.1 | 16.1 | days | mean | 25 | ℃ | FUdR treated worms show that the tub-1(nr2004) mutant has a 12% extended mean lifespan compared to N2 animals. The prolonged longevity of tub-1 worms is not observed when nematode lifespan is recorded in the absence of FUdR. | Aitlhadj et al. | 2010 | 20236608 | doi:10.1016/j.mad.2010.03.002 | Lifespan Observations Database (ID: 4709) | ||||||||||||||||||||||
4 | OB_003290 | Caenorhabditis elegans | N2 |
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increased | 6.25% | 17 | 16 | days | mean | 25 | ℃ | FUdR treated worms show that the tub-1(ok1972) mutant has a 6% extended median lifespan compared to N2 animals. The prolonged longevity of tub-1 worms is not observed when nematode lifespan is recorded in the absence of FUdR. | Aitlhadj et al. | 2010 | 20236608 | doi:10.1016/j.mad.2010.03.002 | Lifespan Observations Database (ID: 4711) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Aitlhadj L, Stürzenbaum SR:
The use of FUdR can cause prolonged longevity in mutant nematodes.
Mech Ageing Dev. 2010; 131: 364-5.
PubMed (ID: 20236608), doi:10.1016/j.mad.2010.03.002
MeSH Terms: Caenorhabditis elegans/drug effects; Floxuridine/pharmacology; Longevity/drug effects