Compound: CCCP - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | CCCP | ||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009115 | ||||||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004510 | Caenorhabditis elegans | N2 |
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increased | 60.00% | 16 | 10 | days | median | 20 | ℃ | All three concentrations of CCCP were able to extend lifespan with statistical significance. Median lifespan was extended by approximately 60% with 10 M CCCP. | Lemire et al. | 2009 | 19442682 | doi:10.1016/j.mad.2009.05.001 | Lifespan Observations Database (ID: 4713) | |||||||||
2 | OB_004511 | Caenorhabditis elegans | N2 |
|
increased | 60.00% | 16 | 10 | days | median | 20 | ℃ | All three concentrations of CCCP were able to extend lifespan with statistical significance. Median lifespan was extended by approximately 60% with 15 M CCCP. | Lemire et al. | 2009 | 19442682 | doi:10.1016/j.mad.2009.05.001 | Lifespan Observations Database (ID: 4714) | |||||||||
3 | OB_004509 | Caenorhabditis elegans | N2 |
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decreased | 0.00% | 10 | 10 | days | median | 20 | ℃ | All three concentrations of CCCP were able to extend lifespan with statistical significance. For the 5 mM CCCP condition, only the maximum lifespan is significantly extended. There was no significant difference in median lifespan. | Lemire et al. | 2009 | 19442682 | doi:10.1016/j.mad.2009.05.001 | Lifespan Observations Database (ID: 4712) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Lemire BD, Behrendt M, DeCorby A, Gásková D:
C. elegans longevity pathways converge to decrease mitochondrial membrane potential.
Mech Ageing Dev. 2009; 130: 461-5.
PubMed (ID: 19442682), doi:10.1016/j.mad.2009.05.001
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/metabolism; Longevity/physiology; Membrane Potential, Mitochondrial/physiology; Mitochondria/metabolism; Mitochondrial Proteins/metabolism