Compound: Nordihydroguaiaretic acid (NDGA) - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Nordihydroguaiaretic acid (NDGA) | ||||||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009116 | ||||||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004514 | Mus musculus | UM-HET3 |
|
increased | 12.09% | 881 | 786 | days | median | 22 | ℃ | male | Male mice treated with NDGA lived approximately 12% longer than controls. | Strong et al. | 2008 | 18631321 | doi:10.1111/j.1474-9726.2008.00414.x | Lifespan Observations Database (ID: 4796) | ||||||||
2 | OB_004515 | Mus musculus | UM-HET3 |
|
none | -0.76% | 780 | 786 | days | median | 22 | ℃ | female | Female mice treated with NDGA were not significantly different than controls. | Strong et al. | 2008 | 18631321 | doi:10.1111/j.1474-9726.2008.00414.x | Lifespan Observations Database (ID: 4797) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Strong R, Miller RA, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E, Nadon NL, Warner HR, Harrison DE:
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice.
Aging Cell. 2008; 7: 641-50.
PubMed (ID: 18631321), PubMed Central (ID: PMC2695675), doi:10.1111/j.1474-9726.2008.00414.x
MeSH Terms: Aspirin/administration & dosage; Genetic Heterogeneity/drug effects; Longevity/drug effects; Longevity/genetics; Nordihydroguaiaretic Acid/administration & dosage