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Compound: Aspirin - Caenorhabditis elegans, Mus musculus

Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Ageing relevance by experimental analysis: yes
Defined by: Name
Ageing relevance by experimental analysis: yes
Defined by: Name

Summary

Compound Name : Aspirin
Species : Caenorhabditis elegans, Mus musculus
Ageing Relevance Analysis :
Observation Type Count Ageing Relevance Source
Ageing Phenotype Observation—Data Type 2
Lifespan Effect
increased 1 yes (Exp. Analysis) [Lifespan Observations Database icon]Lifespan Observations Database
none 1 no (Exp. Analysis) [Lifespan Observations Database icon]Lifespan Observations Database
Total 2
Ageing Factor Stable ID : AF_009117
Download : [xml icon]XML

Observations

Ageing Phenotype

Data Type 1

no ageing phenotype observation—data type 1 available

Data Type 2

Ageing Relevance:
  • yes (Exp. Analysis)
  • yes, but no ageing factor assigned (Exp. Analysis)
  • no (Exp. Analysis)
  • putative (Comp. Analysis)
Organism Ageing Factor Lifespan Observation Reference
# Observation Stable ID Species Strain Gene Compound Other Ageing Factor Significant Lifespan Effect Change Observed Lifespan Reference Lifespan Lifespan Unit Measure Temperature Temperature Unit Sex/Mating Type Description Author Year PubMed DOI Source
1 OB_004688 Caenorhabditis elegans N2
Compound Name Quantity Quantity Unit
Aspirin 100 M
increased 78.57% 7.5 4.2 days 35 ℃ Aspirin (100 M) increased lifespan of C. elegans (N2) at 35 degrees Celsius by 79%. Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5349)
2 OB_004689 Caenorhabditis elegans N2
Compound Name Quantity Quantity Unit
Aspirin 100 M
increased 51.06% 7.1 4.7 days 35 ℃ Aspirin (100 M) increased lifespan of C. elegans (N2) at 35 degrees Celsius by 51%. Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5350)
3 OB_004687 Caenorhabditis elegans N2
Compound Name Quantity Quantity Unit
Aspirin 100 M
increased 44.16% 6.79 4.71 days 35 ℃ Aspirin (100 M) increased lifespan of C. elegans (N2) at 35 degrees Celsius by 44%. Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5348)
4 OB_004674 Caenorhabditis elegans N2
Compound Name Quantity Quantity Unit
Aspirin 100 M
increased 17.52% 25.56 21.75 days 20 ℃ Aspirin (100 M) increased lifespan of C. elegans (N2) by 17.5%. Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5335)
5 OB_004677 Caenorhabditis elegans N2
Compound Name Quantity Quantity Unit
Aspirin 100 M
increased 17.07% 26.48 22.619 days 20 ℃ Aspirin (100 M) increased lifespan of C. elegans (N2) by 17%. Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5338)
6 OB_004678 Caenorhabditis elegans N2
Compound Name Quantity Quantity Unit
Aspirin 200 M
increased 14.36% 25.866 22.619 days 20 ℃ Aspirin (200 M) increased lifespan of C. elegans (N2) by 14%. Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5339)
7 OB_004680 Caenorhabditis elegans sir-2.1(ok434) IV
Compound Name Quantity Quantity Unit
Aspirin 100 M
increased 12.61% 25.985 23.075 days 20 ℃ Aspirin (100 M) increased lifespan of C. elegans (sir-2.1(ok434) IV) by 12.6%. Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5341)
8 OB_004675 Caenorhabditis elegans N2
Compound Name Quantity Quantity Unit
Aspirin 200 M
increased 11.54% 24.26 21.75 days 20 ℃ Aspirin (200 M) increased lifespan of C. elegans (N2) by 11.5%. Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5336)
9 OB_004676 Caenorhabditis elegans N2
Compound Name Quantity Quantity Unit
Aspirin 50 M
increased 9.49% 24.765 22.619 days 20 ℃ Aspirin (50 M) increased lifespan of C. elegans (N2) by 9%. Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5337)
10 OB_004517 Mus musculus UM-HET3
Compound Name Quantity Quantity Unit
Aspirin 3.3 mg/kg/day
increased 8.02% 849 786 days median 22 ℃ male Lifespan of male mice treated with aspirin was approximately 8% longer than controls. Strong et al. 2008 18631321 [DOI icon]doi:10.1111/j.1474-9726.2008.00414.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 4799)
11 OB_004673 Caenorhabditis elegans N2
Compound Name Quantity Quantity Unit
Aspirin 50 M
increased 7.68% 23.42 21.75 days 20 ℃ Aspirin (50 M) did not have a significant effect on C. elegans (N2) lifespan. Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5334)
12 OB_004684 Caenorhabditis elegans daf-2(e1370) III
Compound Name Quantity Quantity Unit
Aspirin 100 M
none 3.41% 53.521 51.757 days 20 ℃ Aspirin (100 M) had no significant effect on lifespan of C. elegans (daf-2(e1370) III). Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5345)
13 OB_004683 Caenorhabditis elegans isp-1(qm150) IV
Compound Name Quantity Quantity Unit
Aspirin 100 M
none 2.69% 25.325 24.661 days 20 ℃ Aspirin (100 M) had no significant effect on lifespan of C. elegans (isp-1(qm150) IV). Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5344)
14 OB_004682 Caenorhabditis elegans clk-1(e2519) III
Compound Name Quantity Quantity Unit
Aspirin 100 M
none 1.15% 27.31 27 days 20 ℃ Aspirin (100 M) had no significant effect on lifespan of C. elegans (clk-1(e2519) III). Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5343)
15 OB_004516 Mus musculus UM-HET3
Compound Name Quantity Quantity Unit
Aspirin 3.3 mg/kg/day
none -0.76% 780 786 days median 22 ℃ female Lifespan of female mice treated with aspirin was not significantly different than controls. Strong et al. 2008 18631321 [DOI icon]doi:10.1111/j.1474-9726.2008.00414.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 4798)
16 OB_004679 Caenorhabditis elegans daf-16 (mu86) I
Compound Name Quantity Quantity Unit
Aspirin 100 M
none -2.75% 12.943 13.309 days 20 ℃ Aspirin (100 M) had no significant effect on lifespan of C. elegans (daf-16 (mu86) I). Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5340)
17 OB_004686 Caenorhabditis elegans par-4(it47)
Compound Name Quantity Quantity Unit
Aspirin 100 M
none -3.66% 19.207 19.936 days 20 ℃ Aspirin (100 M) had no significant effect on lifespan of C. elegans (par-4(it47)). Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5347)
18 OB_004685 Caenorhabditis elegans aak-2(ok524) X
Compound Name Quantity Quantity Unit
Aspirin 100 M
none -3.92% 17.125 17.823 days 20 ℃ Aspirin (100 M) had no significant effect on lifespan of C. elegans (aak-2(ok524) X). Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5346)
19 OB_004681 Caenorhabditis elegans eat-2(ad1116) II
Compound Name Quantity Quantity Unit
Aspirin 100 M
none -3.93% 26.449 27.532 days 20 ℃ Aspirin (100 M) had no significant effect on lifespan of C. elegans (eat-2(ad1116) II). Wan et al. 2013 23485446 [DOI icon]doi:10.1016/j.exger.2013.02.020 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 5342)

Homology Analysis

no homology analysis observation available

References

MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.

  1. Strong R, Miller RA, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E, Nadon NL, Warner HR, Harrison DE:
    Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice.
    Aging Cell. 2008; 7: 641-50.
    [PubMed icon]PubMed (ID: 18631321), [PubMed icon]PubMed Central (ID: PMC2695675), [DOI icon]doi:10.1111/j.1474-9726.2008.00414.x
    MeSH Terms: Aspirin/administration & dosage; Genetic Heterogeneity/drug effects; Longevity/drug effects; Longevity/genetics; Nordihydroguaiaretic Acid/administration & dosage
  2. Wan QL, Zheng SQ, Wu GS, Luo HR:
    Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway.
    Exp Gerontol. 2013; 48: 499-506.
    [PubMed icon]PubMed (ID: 23485446), [DOI icon]doi:10.1016/j.exger.2013.02.020

Sources

Ageing-related Data Sources

Additional Data Sources