Compound: EPEA (eicosapentaenoyl ethanolamide) - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | EPEA (eicosapentaenoyl ethanolamide) | ||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009118 | ||||||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||
1 | OB_004520 | Caenorhabditis elegans | N2 |
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none | -4.88% | 19.5 | 20.5 | days | mean | 20 | ℃ | EPEA has a minimal effect on N2 lifespan in the presence of high food concentrations (11011 c.f.u.ml1 E. coli). | Lucanic et al. | 2011 | 21562563 | doi:10.1038/nature10007 | Lifespan Observations Database (ID: 4824) | |||||||||||||
2 | OB_004519 | Caenorhabditis elegans | daf-2(e1368) |
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decreased | -18.18% | 18 | 22 | days | mean | 20 | ℃ | EPEA treatment reduces lifespan in daf-2(e1368) mutants on control RNAi bacteria by approximately 18%. | Lucanic et al. | 2011 | 21562563 | doi:10.1038/nature10007 | Lifespan Observations Database (ID: 4823) | |||||||||||||
3 | OB_004518 | Caenorhabditis elegans | N2 |
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decreased | -21.05% | 15 | 19 | days | mean | 20 | ℃ | EPEA treatment reduces lifespan in wild-type N2 animals on control RNAi bacteria by approximately 21%. | Lucanic et al. | 2011 | 21562563 | doi:10.1038/nature10007 | Lifespan Observations Database (ID: 4822) | |||||||||||||
4 | OB_004521 | Caenorhabditis elegans | N2 |
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decreased | -37.04% | 17 | 27 | days | mean | 20 | ℃ | EPEA treatment completely suppresses the effect of optimal dietary restriction on wild-type N2 lifespan (110^9 c.f.u.ml1 E. coli. | Lucanic et al. | 2011 | 21562563 | doi:10.1038/nature10007 | Lifespan Observations Database (ID: 4825) | ||||||||||||
5 | OB_004522 | Caenorhabditis elegans | rsks-1(ok1255) |
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decreased | -54.55% | 10 | 22 | days | mean | 20 | ℃ | EPEA treatment suppresses lifespan extension in rsks-1(ok1255) mutants. Lifespan with EPEA treatment was approximately 50% shorter than without treatment. | Lucanic et al. | 2011 | 21562563 | doi:10.1038/nature10007 | Lifespan Observations Database (ID: 4826) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Lucanic M, Held JM, Vantipalli MC, Klang IM, Graham JB, Gibson BW, Lithgow GJ, Gill MS:
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans.
Nature. 2011; 473: 226-9.
PubMed (ID: 21562563), PubMed Central (ID: PMC3093655), doi:10.1038/nature10007
MeSH Terms: Caenorhabditis elegans/physiology; Diet; Ethanolamines/metabolism; Longevity/physiology; Signal Transduction