Compound: ThT (4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylan - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | ThT (4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylan | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009125 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||||||||
1 | OB_003487 | Caenorhabditis elegans | N2 |
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increased | 185.71% | 30 | 10.5 | days | median | 20 | ℃ | hermaphrodite | Exposure to ThT (50M) lengthened median lifespan of age-1(hx546)II mutant approximately 186% relative to N2 control, approximately 88% relative to age-1(hx546)II lifespan. | Alavez et al. | 2011 | 21451522 | doi:10.1038/nature09873 | Lifespan Observations Database (ID: 4914) | |||||||||||||||||||||
2 | OB_004533 | Caenorhabditis elegans | N2 |
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increased | 78.00% | days | max | 20 | ℃ | hermaphrodite | Exposure to ThT (100M) lengthened maximum lifespan of N2 approximately 78%. | Alavez et al. | 2011 | 21451522 | doi:10.1038/nature09873 | Lifespan Observations Database (ID: 4916) | ||||||||||||||||||||||||
3 | OB_004532 | Caenorhabditis elegans | N2 |
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increased | 60.00% | days | median | 20 | ℃ | hermaphrodite | Exposure to ThT (100M) lengthened median lifespan of N2 approximately 60%. | Alavez et al. | 2011 | 21451522 | doi:10.1038/nature09873 | Lifespan Observations Database (ID: 4915) | ||||||||||||||||||||||||
4 | OB_004531 | Caenorhabditis elegans | N2 |
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increased | 57.89% | 30 | 19 | days | max | 20 | ℃ | Exposing sterilized wild-type (N2) nematodes to the fibril-binding flavonoid ThT (4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline chloride)10 at 50 M throughout adult life leads to an approximate 60% increase in maximum lifespan. | Alavez et al. | 2011 | 21451522 | doi:10.1038/nature09873 | Lifespan Observations Database (ID: 4912) | |||||||||||||||||||||||
5 | OB_004530 | Caenorhabditis elegans | N2 |
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increased | 42.86% | 20 | 14 | days | mean | 20 | ℃ | Exposing sterilized wild-type (N2) nematodes to the fibril-binding flavonoid ThT (4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline chloride)10 at 50 M throughout adult life leads to an approximate 40% increase in lifespan. | Alavez et al. | 2011 | 21451522 | doi:10.1038/nature09873 | Lifespan Observations Database (ID: 4911) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Alavez S, Vantipalli MC, Zucker DJ, Klang IM, Lithgow GJ:
Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan.
Nature. 2011; 472: 226-9.
PubMed (ID: 21451522), PubMed Central (ID: PMC3610427), doi:10.1038/nature09873
MeSH Terms: Aging/drug effects; Amyloid/metabolism; Caenorhabditis elegans/metabolism; Homeostasis/drug effects; Longevity/drug effects; Proteins/metabolism; Thiazoles/pharmacology