1 |
OB_004537 |
Mus musculus |
SHR |
|
Compound Name |
Quantity |
Quantity Unit |
1, 1-Dimethylbiguanide hydrochloride |
100 |
mg/kg |
|
|
increased |
20.71% |
577 |
478 |
days |
mean |
22 |
℃ |
|
Metformin treatment started at the age of 3 months increased mean life span of tumor-free mice approximately 21% relative to control. |
Anisimov et al. |
2011 |
21386129 |
|
Lifespan Observations Database (ID: 4975) |
2 |
OB_004535 |
Mus musculus |
SHR |
|
Compound Name |
Quantity |
Quantity Unit |
1, 1-Dimethylbiguanide hydrochloride |
100 |
mg/kg |
|
|
increased |
17.52% |
617 |
525 |
days |
median |
22 |
℃ |
|
Metformin treatment started at the age of 3 months increased median life span approximately 18% relative to control. |
Anisimov et al. |
2011 |
21386129 |
|
Lifespan Observations Database (ID: 4973) |
3 |
OB_004534 |
Mus musculus |
SHR |
|
Compound Name |
Quantity |
Quantity Unit |
1, 1-Dimethylbiguanide hydrochloride |
100 |
mg/kg |
|
|
increased |
14.09% |
583 |
511 |
days |
mean |
22 |
℃ |
|
Metformin treatment started at the age of 3 months increased mean life span approximately 14% relative to control. |
Anisimov et al. |
2011 |
21386129 |
|
Lifespan Observations Database (ID: 4972) |
4 |
OB_004541 |
Mus musculus |
SHR |
|
Compound Name |
Quantity |
Quantity Unit |
1, 1-Dimethylbiguanide hydrochloride |
100 |
mg/kg |
|
|
increased |
7.06% |
652 |
609 |
days |
mean |
22 |
℃ |
|
Metformin treatment started at the age of 9 months increased mean life span of tumor-free mice approximately 7% relative to control. |
Anisimov et al. |
2011 |
21386129 |
|
Lifespan Observations Database (ID: 4979) |
5 |
OB_004539 |
Mus musculus |
SHR |
|
Compound Name |
Quantity |
Quantity Unit |
1, 1-Dimethylbiguanide hydrochloride |
100 |
mg/kg |
|
|
increased |
6.60% |
630 |
591 |
days |
median |
22 |
℃ |
|
Metformin treatment started at the age of 9 months increased median life span approximately 7% relative to control. |
Anisimov et al. |
2011 |
21386129 |
|
Lifespan Observations Database (ID: 4977) |
6 |
OB_004538 |
Mus musculus |
SHR |
|
Compound Name |
Quantity |
Quantity Unit |
1, 1-Dimethylbiguanide hydrochloride |
100 |
mg/kg |
|
|
increased |
6.17% |
619 |
583 |
days |
mean |
22 |
℃ |
|
Metformin treatment started at the age of 9 months increased mean life span approximately 6% relative to control. |
Anisimov et al. |
2011 |
21386129 |
|
Lifespan Observations Database (ID: 4976) |
7 |
OB_004536 |
Mus musculus |
SHR |
|
Compound Name |
Quantity |
Quantity Unit |
1, 1-Dimethylbiguanide hydrochloride |
100 |
mg/kg |
|
|
none |
3.29% |
972 |
941 |
days |
max |
22 |
℃ |
|
Metformin treatment started at the age of 3 months increased maximum life span approximately 3% relative to control. |
Anisimov et al. |
2011 |
21386129 |
|
Lifespan Observations Database (ID: 4974) |
8 |
OB_004544 |
Mus musculus |
SHR |
|
Compound Name |
Quantity |
Quantity Unit |
1, 1-Dimethylbiguanide hydrochloride |
100 |
mg/kg |
|
|
none |
2.66% |
966 |
941 |
days |
max |
22 |
℃ |
|
Metformin treatment started at the age of 15 months had no significant effect on maximum lifespan relative to control. |
Anisimov et al. |
2011 |
21386129 |
|
Lifespan Observations Database (ID: 4982) |
9 |
OB_004543 |
Mus musculus |
SHR |
|
Compound Name |
Quantity |
Quantity Unit |
1, 1-Dimethylbiguanide hydrochloride |
100 |
mg/kg |
|
|
none |
0.00% |
636 |
636 |
days |
median |
22 |
℃ |
|
Metformin treatment started at the age of 15 months had no significant effect on median lifespan relative to control. |
Anisimov et al. |
2011 |
21386129 |
|
Lifespan Observations Database (ID: 4981) |
10 |
OB_004542 |
Mus musculus |
SHR |
|
Compound Name |
Quantity |
Quantity Unit |
1, 1-Dimethylbiguanide hydrochloride |
100 |
mg/kg |
|
|
none |
-3.14% |
647 |
668 |
days |
mean |
22 |
℃ |
|
Metformin treatment started at the age of 15 months had no significant effect on mean lifespan relative to control. |
Anisimov et al. |
2011 |
21386129 |
|
Lifespan Observations Database (ID: 4980) |
11 |
OB_004540 |
Mus musculus |
SHR |
|
Compound Name |
Quantity |
Quantity Unit |
1, 1-Dimethylbiguanide hydrochloride |
100 |
mg/kg |
|
|
decreased |
-9.14% |
855 |
941 |
days |
max |
22 |
℃ |
|
Metformin treatment started at the age of 9 months decreased maximum life span approximately 9% relative to control. |
Anisimov et al. |
2011 |
21386129 |
|
Lifespan Observations Database (ID: 4978) |
12 |
OB_004545 |
Mus musculus |
SHR |
|
Compound Name |
Quantity |
Quantity Unit |
1, 1-Dimethylbiguanide hydrochloride |
100 |
mg/kg |
|
|
decreased |
-12.80% |
627 |
719 |
days |
mean |
22 |
℃ |
|
Metformin treatment started at the age of 15 months decreased mean lifespan of tumor-free mice approximately 13% relative to control. |
Anisimov et al. |
2011 |
21386129 |
|
Lifespan Observations Database (ID: 4983) |