Compound: Glaucarubinone - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Glaucarubinone | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009129 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004560 | Caenorhabditis elegans |
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increased | 8.85% | 33.2 | 30.5 | days | max | The maximum observable effect on maxi- mum life span (80th percentile) was 2.7 days, which occurred at a concentration of 100 nanomolar. | Zarse et al. | 2011 | 21264793 | doi:10.1055/s-0030-1270524 | Lifespan Observations Database (ID: 5087) | ||||||||||||
2 | OB_004559 | Caenorhabditis elegans |
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increased | 8.51% | 25.5 | 23.5 | days | mean | The maximum observable effect on mean life span was 1.9 days, which occurred at a concentration of 100 nanomolar. | Zarse et al. | 2011 | 21264793 | doi:10.1055/s-0030-1270524 | Lifespan Observations Database (ID: 5086) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Zarse K, Bossecker A, Müller-Kuhrt L, Siems K, Hernandez MA, Berendsohn WG, Birringer M, Ristow M:
The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans.
Horm Metab Res. 2011; 43: 241-3.
PubMed (ID: 21264793), doi:10.1055/s-0030-1270524
MeSH Terms: Adipose Tissue/drug effects; Caenorhabditis elegans/drug effects; Glaucarubin/analogs & derivatives; Longevity/drug effects; Mitochondria/metabolism; Plant Extracts/pharmacology; Simaroubaceae/chemistry