Compound: Cholesterol - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Cholesterol | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009130 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004561 | Caenorhabditis elegans | N2 |
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decreased | -36.00% | 16 | 25 | days | mean | 20 | ℃ | N2 strain worms grown in the absence of cholesterol showed about a 40% reduction in MLS, whereas all other groups showed essentially the same normal MLS (25.09 days), suggesting that as long as worms receive 1 g/ml of cholesterol, their MLS remained unchanged. | Cheong et al. | 2011 | 21186286 | doi:10.1074/jbc.M110.189183 | Lifespan Observations Database (ID: 5088) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Cheong MC, Na K, Kim H, Jeong SK, Joo HJ, Chitwood DJ, Paik YK:
A potential biochemical mechanism underlying the influence of sterol deprivation stress on Caenorhabditis elegans longevity.
J Biol Chem. 2011; 286: 7248-56.
PubMed (ID: 21186286), PubMed Central (ID: PMC3044981), doi:10.1074/jbc.M110.189183
MeSH Terms: Caenorhabditis elegans/metabolism; Cholesterol/deficiency; Longevity/physiology; Oxidative Stress/physiology; Sitosterols/metabolism