Compound: 25-azacoprostane - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | 25-azacoprostane | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009131 | ||||||||||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004564 | Caenorhabditis elegans | gas-1(fc2) |
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increased | 53.85% | 20 | 13 | days | mean | 20 | ℃ | Treatment of gas-1(fc2) mutant worms with 25 M Aza in the presence of 5 g/ml of sitosterol caused a reduction in MLS compared with those grown in the presence of sitosterol alone. | Cheong et al. | 2011 | 21186286 | doi:10.1074/jbc.M110.189183 | Lifespan Observations Database (ID: 5091) | |||||||||
2 | OB_004566 | Caenorhabditis elegans | daf-2(e1370) |
|
none | 2.78% | 37 | 36 | days | mean | 20 | ℃ | Treatment of daf-2(e1370) mutant worms with 25 M Aza in the presence of 5 g/ml of sitosterol had no significant effect on MLS compared with those grown in the presence of sitosterol alone. | Cheong et al. | 2011 | 21186286 | doi:10.1074/jbc.M110.189183 | Lifespan Observations Database (ID: 5093) | |||||||||
3 | OB_004565 | Caenorhabditis elegans | mev-1(kn1) |
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none | 0.00% | 16 | 16 | days | mean | 20 | ℃ | Treatment of mev-1(kn1) mutant worms with 25 M Aza in the presence of 5 g/ml of sitosterol had no significant effect on MLS compared with those grown in the presence of sitosterol alone. | Cheong et al. | 2011 | 21186286 | doi:10.1074/jbc.M110.189183 | Lifespan Observations Database (ID: 5092) | |||||||||
4 | OB_004562 | Caenorhabditis elegans | N2 |
|
decreased | -34.52% | 16.5 | 25.2 | days | mean | 20 | ℃ | Treatment of N2 worms with 2M Aza in the presence of 5 g/ml of sitosterol caused a 35% reduction in MLS (16.5 days) compared with those grown in the presence of sitosterol alone (25.2 days) | Cheong et al. | 2011 | 21186286 | doi:10.1074/jbc.M110.189183 | Lifespan Observations Database (ID: 5089) | |||||||||
5 | OB_004563 | Caenorhabditis elegans | daf-16(mu86) |
|
decreased | -37.77% | 11.7 | 18.8 | days | mean | 20 | ℃ | Treatment of daf-16(mu86) mutant worms with 25 M Aza in the presence of 5 g/ml of sitosterol caused a 38% reduction in MLS compared with those grown in the presence of sitosterol alone. | Cheong et al. | 2011 | 21186286 | doi:10.1074/jbc.M110.189183 | Lifespan Observations Database (ID: 5090) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Cheong MC, Na K, Kim H, Jeong SK, Joo HJ, Chitwood DJ, Paik YK:
A potential biochemical mechanism underlying the influence of sterol deprivation stress on Caenorhabditis elegans longevity.
J Biol Chem. 2011; 286: 7248-56.
PubMed (ID: 21186286), PubMed Central (ID: PMC3044981), doi:10.1074/jbc.M110.189183
MeSH Terms: Caenorhabditis elegans/metabolism; Cholesterol/deficiency; Longevity/physiology; Oxidative Stress/physiology; Sitosterols/metabolism