Compound: Sibutramine - Mus musculus, Rattus norvegicus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Sibutramine | ||||||||||||||||
Species | : | Mus musculus, Rattus norvegicus | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009133 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004620 | Mus musculus | CD-1 |
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none | 22 | ℃ | There were no significant differences in lifespan among groups in mice, even in the highest dosage group. | Smith et al. | 2011 | 21079617 | doi:10.1038/ijo.2010.247 | Lifespan Observations Database (ID: 5171) | ||||||||||||||
2 | OB_004621 | Rattus norvegicus | Charles River Laboratory Sprague-Dawley CD |
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none | 22 | ℃ | There were no significant differences in lifespan in rats. | Smith et al. | 2011 | 21079617 | doi:10.1038/ijo.2010.247 | Lifespan Observations Database (ID: 5172) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Smith DL, Robertson HT, Desmond RA, Nagy TR, Allison DB:
No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight.
Int J Obes (Lond). 2011; 35: 652-7.
PubMed (ID: 21079617), PubMed Central (ID: PMC3091992), doi:10.1038/ijo.2010.247
MeSH Terms: Appetite Depressants/pharmacology; Cyclobutanes/pharmacology; Eating/drug effects; Longevity/drug effects; Serotonin Uptake Inhibitors/pharmacology; Weight Loss/drug effects