Compound: Dafadine-A - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Dafadine-A | ||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009135 | ||||||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||||||||
1 | OB_004625 | Caenorhabditis elegans | N2 |
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increased | 29.39% | 29.5 | 22.8 | days | mean | 15 | ℃ | Control N2 animals listed as "WT" were maintained on control plates containing DMSO. This lifespan was compared with that of N2 animals transferred to plates containing 50 um dafadine-A beginning at the L4 stage of development. | Luciani et al. | 2011 | 22057127 | doi:10.1038/nchembio.698 | Lifespan Observations Database (ID: 5257) | |||||||||||||||||||||||
2 | OB_004624 | Caenorhabditis elegans | N2 |
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increased | 16.23% | 26.5 | 22.8 | days | mean | 15 | ℃ | Control N2 animals listed as "WT" were maintained on control plates containing DMSO. This lifespan was compared with that of N2 animals transferred to plates containing 25 um dafadine-A beginning at the L4 stage of development. | Luciani et al. | 2011 | 22057127 | doi:10.1038/nchembio.698 | Lifespan Observations Database (ID: 5256) | |||||||||||||||||||||||
3 | OB_004623 | Caenorhabditis elegans |
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increased | 12.28% | 25.6 | 22.8 | days | mean | 15 | ℃ | Control N2 animals listed as "WT" were maintained on control plates containing DMSO. This lifespan was compared with that of N2 animals transferred to plates containing 6.25 um dafadine-A beginning at the L4 stage of development. | Luciani et al. | 2011 | 22057127 | doi:10.1038/nchembio.698 | Lifespan Observations Database (ID: 5255) | ||||||||||||||||||||||||
4 | OB_004627 | Caenorhabditis elegans |
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increased | 8.21% | 22.4 | 20.7 | days | mean | 20 | ℃ | Control N2 worms, represented as "WT," were raised on control plates containing DMSO. Worm lifespan was compared to N2 worms that had been transferred to plates containing 25 uM dafadine-A beginning at the L4 stage of development. | Luciani et al. | 2011 | 22057127 | doi:10.1038/nchembio.698 | Lifespan Observations Database (ID: 5259) | ||||||||||||||||||||||||
5 | OB_004626 | Caenorhabditis elegans | N2 |
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increased | 5.31% | 21.8 | 20.7 | days | mean | 20 | ℃ | Control N2 worms, represented as "WT," were raised on control plates containing DMSO. Worm lifespan was compared to N2 worms that had been transferred to plates containing 6.25 uM dafadine-A beginning at the L4 stage of development. | Luciani et al. | 2011 | 22057127 | doi:10.1038/nchembio.698 | Lifespan Observations Database (ID: 5258) | |||||||||||||||||||||||
6 | OB_003738 | Caenorhabditis elegans | daf-9(dh6) mutant |
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decreased | -16.46% | 19.8 | 23.7 | days | mean | 15 | ℃ | Loss of function daf-9 mutants, represented as "WT," were raised on control plates containing DMSO. Worm lifespan was compared to daf-9 mutants that had been transferred to plates containing 50 uM dafadine-A beginning at the L4 stage of development. | Luciani et al. | 2011 | 22057127 | doi:10.1038/nchembio.698 | Lifespan Observations Database (ID: 5262) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Luciani GM, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ:
Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.
Nat Chem Biol. 2011; 7: 891-3.
PubMed (ID: 22057127), doi:10.1038/nchembio.698
MeSH Terms: Caenorhabditis elegans Proteins/antagonists & inhibitors; Caenorhabditis elegans/drug effects; Caenorhabditis elegans/growth & development; Cytochrome P-450 Enzyme System/antagonists & inhibitors; Enzyme Inhibitors/pharmacology; Isoxazoles/pharmacology; Longevity/drug effects; Piperidines/pharmacology; Pyridines/pharmacology