1 |
OB_003746 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
men-1 |
Caenorhabditis elegans |
175079 |
RNAi knockdown |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
increased |
30.00% |
|
|
days |
mean |
20 |
℃ |
|
Mean lifespan of men-1 RNAi knockdown worms was only 53% of controls, but malate addition still extended mean lifespan by 30%. |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5279) |
2 |
OB_003754 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
R53.1 |
Caenorhabditis elegans |
3565030 |
RNAi knockdown |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
increased |
29.00% |
|
|
days |
mean |
20 |
℃ |
|
flad-1 RNAi knockdown had a mean lifespan of 71% of the control, and malate treatment completely restored the lifespan back to that of the control. |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5286) |
3 |
OB_003748 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mdh-1 |
Caenorhabditis elegans |
179041 |
RNAi knockdown |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
increased |
26.00% |
|
|
days |
mean |
20 |
℃ |
|
The mean lifespan of mdh-1 knockdown worms was 66% of controls, but malate addition extended mean lifespan of the RNAi treatment by 26%, nearly back to that observed in the control worms. |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5280) |
4 |
OB_003751 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sdha-1 |
Caenorhabditis elegans |
181108 |
RNAi knockdown |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
increased |
20.00% |
|
|
days |
mean |
20 |
℃ |
|
sdha-1 knockdown worms had a mean lifespan 78% of controls and malate treatment increased mean lifespan by 20%. |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5283) |
5 |
OB_004628 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
increased |
14.00% |
|
|
days |
mean |
20 |
℃ |
|
Malate increased mean lifespan by 14% and the increase was consistently observed (p<0.001) in nine total replicates using either live E. coli (n=6) or heat killed E. coli (n=3) as the food source. |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5268) |
6 |
OB_003753 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
F48E8.3 |
Caenorhabditis elegans |
175751 |
RNAi knockdown |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
increased |
10.00% |
|
|
days |
mean |
20 |
℃ |
|
F48E8.3 RNAi knockdown worms lived 79% as long as controls. Malate addition did not extend lifespan and caused a 10% decrease in lifespan. |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5285) |
7 |
OB_003745 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
skn-1 |
Caenorhabditis elegans |
177343 |
RNAi knockdown |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
increased |
9.00% |
|
|
days |
mean |
20 |
℃ |
|
Malate extended the lifespan of skn-1 RNAi nematodes by 9%. |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5278) |
8 |
OB_003740 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sir-2.1 |
Caenorhabditis elegans |
177924 |
loss of function |
434 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
none |
|
|
|
days |
mean |
20 |
℃ |
|
Malate addition was unable to extend the lifespan of sir-2.1(ok434) mutant worms |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5273) |
9 |
OB_003741 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad116 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
none |
|
|
|
days |
mean |
20 |
℃ |
|
Malate did not extend the lifespan of long-lived eat-2(ad1116) worms. |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5274) |
10 |
OB_003743 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mgDf50 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
none |
|
|
|
days |
mean |
20 |
℃ |
|
Treatment with malate did not extend the lifespan of daf-16(mgDf50) worms. |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5276) |
11 |
OB_003744 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hsf-1 |
Caenorhabditis elegans |
173078 |
loss of function |
sy441 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
none |
|
|
|
days |
mean |
20 |
℃ |
|
Malate failed to significantly extend the lifespan of heat shock factor-1 mutant, hsf-1(sy441) worms. |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5277) |
12 |
OB_003749 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
gei-7 |
Caenorhabditis elegans |
178583 |
RNAi knockdown |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
none |
|
|
|
days |
mean |
20 |
℃ |
|
Mean lifespan of gei-7 RNAi knockdown worms was 62% of controls and the lifespan was not statistically different in the presence of malate (log-rank p=0.24). |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5281) |
13 |
OB_003752 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sdha-2 |
Caenorhabditis elegans |
172968 |
RNAi knockdown |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
none |
|
|
|
days |
mean |
20 |
℃ |
|
Malate addition did not significantly alter sdha-2 RNAi lifespan (log-rank p=0.95). |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5284) |