Compound: Fumarate - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Fumarate | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009137 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||||||||
1 | OB_003750 | Caenorhabditis elegans | N2 |
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increased | 18.00% | days | mean | 20 | ℃ | Fumarate addition extended lifespan by 18% in fum-1 RNAi knockdown worms. | Edwards et al. | 2013 | 23472183 | doi:10.1371/journal.pone.0058345 | Lifespan Observations Database (ID: 5282) | ||||||||||||||||||||||||
2 | OB_004629 | Caenorhabditis elegans | N2 |
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increased | 16.00% | days | mean | 20 | ℃ | Fumarate increased mean lifespan by 16% (p<0.001 n=4). | Edwards et al. | 2013 | 23472183 | doi:10.1371/journal.pone.0058345 | Lifespan Observations Database (ID: 5269) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Edwards CB, Copes N, Brito AG, Canfield J, Bradshaw PC:
Malate and fumarate extend lifespan in Caenorhabditis elegans.
PLoS ONE. 2013; 8: e58345.
PubMed (ID: 23472183), PubMed Central (ID: PMC3589421), doi:10.1371/journal.pone.0058345