1 |
OB_004643 |
Caenorhabditis elegans |
sir-2.1 (N3908) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
|
increased |
26.67% |
15.2 |
12 |
days |
mean |
20 |
℃ |
|
sir-2.1 (OE3908) lifespan treated with ascr#2 (400 nM) was 26% greater than control sir-2.1 (OE3908). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5303) |
2 |
OB_004634 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
1.25 |
M |
Ascr#3 |
1.25 |
M |
|
|
increased |
22.62% |
20.6 |
16.8 |
days |
mean |
20 |
℃ |
|
Mean lifespan of L4-stage worms transferred onto plates containing ascr#2 (1.25 M) and ascr#3 (1.25 M) was increased by 23%. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5288) |
3 |
OB_004646 |
Caenorhabditis elegans |
sir-2.1 OE (NL3909); daf-16(mgDf50) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
|
increased |
21.15% |
12.6 |
10.4 |
days |
mean |
20 |
℃ |
|
sir-2.1 OE (NL3909); daf-16(mgDf50) lifespan treated with ascr#2 (400 nM) was 21% greater than control sir-2.1 OE (NL3909); daf-16(mgDf50). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5306) |
4 |
OB_004668 |
Caenorhabditis elegans |
daf-37 OE |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
|
increased |
18.87% |
25.2 |
21.2 |
|
|
20 |
℃ |
|
Lifespan of daf-37 OE nematodes treated with ascr#2 (400 nM) was 18% greater than control daf-37 OE. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5328) |
5 |
OB_004645 |
Caenorhabditis elegans |
sir-2.1 OE (NL3909); daf-16(mgDf50) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
4 |
nM |
|
|
increased |
18.27% |
12.3 |
10.4 |
days |
mean |
20 |
℃ |
|
sir-2.1 OE (NL3909); daf-16(mgDf50) lifespan treated with ascr#2 (4 nM) was 18% greater than control sir-2.1 OE (NL3909); daf-16(mgDf50). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5305) |
6 |
OB_004666 |
Caenorhabditis elegans |
daf-7(e1372);daf-3(e1376) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
|
increased |
18.24% |
17.5 |
14.8 |
|
|
20 |
℃ |
|
Lifespan of daf-7(e1372);daf-3(e1376) nematodes treated with ascr#2 (400 nM) was 18% greater than control daf-7(e1372);daf-3(e1376). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5326) |
7 |
OB_004670 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
Other Ageing Factor Name |
Additional Information |
Heat stress |
Survivorship of adult worms at 35 C. |
|
increased |
18.13% |
8.34 |
7.06 |
|
mean |
20 |
℃ |
|
Lifespan of N2 treated with ascr#2 (400 nM), under heat stress, was 18% greater than control. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5330) |
8 |
OB_004644 |
Caenorhabditis elegans |
sir-2.1 OE (NL3909); daf-16(mgDf50) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
0.04 |
nM |
|
|
increased |
16.35% |
12.1 |
10.4 |
days |
mean |
20 |
℃ |
|
sir-2.1 OE (NL3909); daf-16(mgDf50) lifespan treated with ascr#2 (0.04 nM) was 16% greater than control sir-2.1 OE (NL3909); daf-16(mgDf50). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5304) |
9 |
OB_004635 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
1 |
M |
Ascr#3 |
1 |
M |
|
|
increased |
14.89% |
21.6 |
18.8 |
days |
mean |
20 |
℃ |
|
Mean lifespan of L4-stage worms transferred onto plates containing ascr#2 (1 M) and ascr#3 (1 M) was increased by 15%. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5289) |
10 |
OB_004637 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
|
increased |
14.39% |
15.1 |
13.2 |
days |
mean |
20 |
℃ |
|
Mean lifespan of L4-stage worms transferred onto plates containing ascr#2 (400 nM) was increased by 14%. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5291) |
11 |
OB_004669 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
200 |
nM |
|
Other Ageing Factor Name |
Additional Information |
Heat stress |
Survivorship of adult worms at 35 C. |
|
increased |
13.46% |
8.01 |
7.06 |
|
mean |
20 |
℃ |
|
Lifespan of N2 treated with ascr#2 (200 nM), under heat stress, was 18% greater than control. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5329) |
12 |
OB_004633 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
0.75 |
M |
Ascr#3 |
0.75 |
M |
|
|
increased |
12.50% |
18.9 |
16.8 |
days |
mean |
20 |
℃ |
|
Mean lifespan of L4-stage worms transferred onto plates containing ascr#2 (0.75 M) and ascr#3 (0.75 M) was increased by 12.5%. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5287) |
13 |
OB_004651 |
Caenorhabditis elegans |
daf-16 (mu86) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
4 |
nM |
|
|
increased |
12.50% |
11.7 |
10.4 |
days |
mean |
20 |
℃ |
|
daf-16 (mu86) lifespan treated with ascr#2 (4 nM) was 12.5% greater than control daf-16 (mu86). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5311) |
14 |
OB_004654 |
Caenorhabditis elegans |
daf-16 (mu86) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
|
increased |
11.68% |
15.3 |
13.7 |
days |
mean |
20 |
℃ |
|
daf-16 (mu86) lifespan treated with ascr#2 (400 nM) was 12% greater than control daf-16 (mu86). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5314) |
15 |
OB_004642 |
Caenorhabditis elegans |
sir-2.1 (N3908) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
4 |
nM |
|
|
increased |
10.83% |
13.3 |
12 |
days |
mean |
20 |
℃ |
|
sir-2.1 (OE3908) lifespan treated with ascr#2 (4 nM) was not significantly different than control sir-2.1 (OE3908). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5302) |
16 |
OB_004636 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
4 |
nM |
|
|
increased |
9.85% |
14.5 |
13.2 |
days |
mean |
20 |
℃ |
|
Mean lifespan of L4-stage worms transferred onto plates containing ascr#2 (4 nM) was increased by 9.8%. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5290) |
17 |
OB_004652 |
Caenorhabditis elegans |
daf-16 (mu86) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
4 |
nM |
|
|
increased |
9.49% |
15 |
13.7 |
days |
mean |
20 |
℃ |
|
daf-16 (mu86) lifespan treated with ascr#2 (4 nM) was 10% greater than control daf-16 (mu86). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5312) |
18 |
OB_004664 |
Caenorhabditis elegans |
daf-7(e1372);daf-3(e1376) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
|
increased |
9.09% |
16.8 |
15.4 |
|
|
20 |
℃ |
|
Lifespan of daf-7(e1372);daf-3(e1376) nematodes treated with ascr#2 (400 nM) was not significantly different than control daf-7(e1372);daf-3(e1376). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5324) |
19 |
OB_004658 |
Caenorhabditis elegans |
daf-12 (rh411rh61) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
|
increased |
8.74% |
11.2 |
10.3 |
days |
mean |
20 |
℃ |
|
daf-12 (rh411rh61) lifespan treated with ascr#2 (400 nM) was not significantly different than control daf-12 (rh411rh61). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5318) |
20 |
OB_004650 |
Caenorhabditis elegans |
daf-16 (mu86) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
0.04 |
nM |
|
|
increased |
8.65% |
11.3 |
10.4 |
days |
mean |
20 |
℃ |
|
daf-16 (mu86) lifespan treated with ascr#2 (0.04 nM) was not significantly different than control daf-16 (mu86). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5310) |
21 |
OB_004660 |
Caenorhabditis elegans |
daf-12 (rh411rh61) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
|
increased |
8.49% |
11.5 |
10.6 |
days |
mean |
20 |
℃ |
|
daf-12 (rh411rh61) lifespan treated with ascr#2 (400 nM) was 8% greater than control daf-12 (rh411rh61). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5320) |
22 |
OB_004641 |
Caenorhabditis elegans |
sir-2.1 (N3908) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
0.04 |
nM |
|
|
increased |
8.33% |
13 |
12 |
days |
mean |
20 |
℃ |
|
sir-2.1 (OE3908) lifespan treated with ascr#2 (0.04 nM) was not significantly different than control sir-2.1 (OE3908). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5301) |
23 |
OB_004662 |
Caenorhabditis elegans |
daf-2 (e1368) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
|
increased |
7.57% |
19.9 |
18.5 |
|
|
20 |
℃ |
|
Lifespan of daf-2 (e1368) nematodes treated with ascr#2 (400 nM) was not significantly different than control daf-2 (e1368). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5322) |
24 |
OB_004653 |
Caenorhabditis elegans |
daf-16 (mu86) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
40 |
nM |
|
|
none |
2.19% |
14 |
13.7 |
days |
mean |
20 |
℃ |
|
daf-16 (mu86) lifespan treated with ascr#2 (40 nM) was not significantly different than control daf-16 (mu86). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5313) |
25 |
OB_003757 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sir-2.1 |
Caenorhabditis elegans |
177924 |
loss of function |
ok434 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
0.04 |
nM |
|
|
none |
-4.00% |
12 |
12.5 |
days |
mean |
20 |
℃ |
|
sir-2.1 (ok434) lifespan treated with ascr#2 (0.04 nM) was not significantly different than control. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5296) |
26 |
OB_004672 |
Caenorhabditis elegans |
sir-2.1(ok434) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
Other Ageing Factor Name |
Additional Information |
Heat stress |
Survivorship of adult worms at 35 C. |
|
decreased |
-5.60% |
7.42 |
7.86 |
|
mean |
20 |
℃ |
|
Lifespan of sir-2.1(ok434) treated with ascr#2 (400 nM), under heat stress, was not significantly different than control sir-2.1(ok434). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5332) |
27 |
OB_003756 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sir-2.1 |
Caenorhabditis elegans |
177924 |
loss of function |
ok434 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
4 |
nM |
|
|
decreased |
-5.60% |
11.8 |
12.5 |
days |
mean |
20 |
℃ |
|
sir-2.1 (ok434) lifespan treated with ascr#2 (4 nM) was not significantly different than control. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5295) |
28 |
OB_003758 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sir-2.1 |
Caenorhabditis elegans |
177924 |
loss of function |
ok434 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
400 |
nM |
|
|
decreased |
-5.60% |
11.8 |
12.5 |
days |
mean |
20 |
℃ |
|
sir-2.1 (ok434) lifespan treated with ascr#2 (400 nM) was not significantly different than control. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5297) |
29 |
OB_004671 |
Caenorhabditis elegans |
sir-2.1(ok434) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
200 |
nM |
|
Other Ageing Factor Name |
Additional Information |
Heat stress |
Survivorship of adult worms at 35 C. |
|
decreased |
-6.74% |
7.33 |
7.86 |
|
mean |
20 |
℃ |
|
Lifespan of sir-2.1(ok434) treated with ascr#2 (200 nM), under heat stress, was not significantly different than control sir-2.1(ok434). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5331) |