1 |
OB_004667 |
Caenorhabditis elegans |
daf-7(e1372);daf-3(e1376) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
400 |
nM |
|
|
increased |
25.00% |
18.5 |
14.8 |
|
|
20 |
℃ |
|
Lifespan of daf-7(e1372);daf-3(e1376) nematodes treated with ascr#3 (400 nM) was 25% greater than control daf-7(e1372);daf-3(e1376). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5327) |
2 |
OB_004634 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
1.25 |
M |
Ascr#3 |
1.25 |
M |
|
|
increased |
22.62% |
20.6 |
16.8 |
days |
mean |
20 |
℃ |
|
Mean lifespan of L4-stage worms transferred onto plates containing ascr#2 (1.25 M) and ascr#3 (1.25 M) was increased by 23%. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5288) |
3 |
OB_004640 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
400 |
nM |
|
|
increased |
21.21% |
16 |
13.2 |
days |
mean |
20 |
℃ |
|
Mean lifespan of L4-stage worms transferred onto plates containing ascr#3 (400 nM) was increased by 21.2%. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5294) |
4 |
OB_004661 |
Caenorhabditis elegans |
daf-12 (rh411rh61) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
400 |
nM |
|
|
increased |
18.87% |
12.6 |
10.6 |
days |
mean |
20 |
℃ |
|
daf-12 (rh411rh61) lifespan treated with ascr#3 (400 nM) was not significantly different than control daf-12 (rh411rh61). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5321) |
5 |
OB_004648 |
Caenorhabditis elegans |
sir-2.1 OE (NL3909); daf-16(mgDf50) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
4 |
nM |
|
|
increased |
16.35% |
12.1 |
10.4 |
days |
mean |
20 |
℃ |
|
sir-2.1 OE (NL3909); daf-16(mgDf50) lifespan treated with ascr#3 (4 nM) was 16% greater than control sir-2.1 OE (NL3909); daf-16(mgDf50). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5308) |
6 |
OB_004635 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
1 |
M |
Ascr#3 |
1 |
M |
|
|
increased |
14.89% |
21.6 |
18.8 |
days |
mean |
20 |
℃ |
|
Mean lifespan of L4-stage worms transferred onto plates containing ascr#2 (1 M) and ascr#3 (1 M) was increased by 15%. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5289) |
7 |
OB_004647 |
Caenorhabditis elegans |
sir-2.1 OE (NL3909); daf-16(mgDf50) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
0.04 |
nM |
|
|
increased |
14.42% |
11.9 |
10.4 |
days |
mean |
20 |
℃ |
|
sir-2.1 OE (NL3909); daf-16(mgDf50) lifespan treated with ascr#3 (0.04 nM) was 14% greater than control sir-2.1 OE (NL3909); daf-16(mgDf50). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5307) |
8 |
OB_004649 |
Caenorhabditis elegans |
sir-2.1 OE (NL3909); daf-16(mgDf50) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
400 |
nM |
|
|
increased |
14.42% |
11.9 |
10.4 |
days |
mean |
20 |
℃ |
|
sir-2.1 OE (NL3909); daf-16(mgDf50) lifespan treated with ascr#3 (400 nM) was 14% greater than control sir-2.1 OE (NL3909); daf-16(mgDf50). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5309) |
9 |
OB_004665 |
Caenorhabditis elegans |
daf-7(e1372);daf-3(e1376) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
400 |
nM |
|
|
increased |
12.99% |
17.4 |
15.4 |
|
|
20 |
℃ |
|
Lifespan of daf-7(e1372);daf-3(e1376) nematodes treated with ascr#3 (400 nM) was 13% greater than control daf-7(e1372);daf-3(e1376). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5325) |
10 |
OB_004639 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
4 |
nM |
|
|
increased |
12.88% |
14.9 |
13.2 |
days |
mean |
20 |
℃ |
|
Mean lifespan of L4-stage worms transferred onto plates containing ascr#3 (4 nM) was increased by 12.9%. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5293) |
11 |
OB_004633 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#2 |
0.75 |
M |
Ascr#3 |
0.75 |
M |
|
|
increased |
12.50% |
18.9 |
16.8 |
days |
mean |
20 |
℃ |
|
Mean lifespan of L4-stage worms transferred onto plates containing ascr#2 (0.75 M) and ascr#3 (0.75 M) was increased by 12.5%. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5287) |
12 |
OB_004638 |
Caenorhabditis elegans |
N2 |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
0.04 |
nM |
|
|
increased |
10.61% |
14.6 |
13.2 |
days |
mean |
20 |
℃ |
|
Mean lifespan of L4-stage worms transferred onto plates containing ascr#3 (0.04 nM) was increased by 10.6%. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5292) |
13 |
OB_004659 |
Caenorhabditis elegans |
daf-12 (rh411rh61) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
400 |
nM |
|
|
increased |
9.71% |
11.3 |
10.3 |
days |
mean |
20 |
℃ |
|
daf-12 (rh411rh61) lifespan treated with ascr#3 (400 nM) was not significantly different than control daf-12 (rh411rh61). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5319) |
14 |
OB_004663 |
Caenorhabditis elegans |
daf-2 (e1368) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
400 |
nM |
|
|
increased |
9.19% |
20.2 |
18.5 |
|
|
20 |
℃ |
|
Lifespan of daf-2 (e1368) nematodes treated with ascr#3 (400 nM) was not significantly different than control daf-2 (e1368). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5323) |
15 |
OB_004655 |
Caenorhabditis elegans |
daf-16 (mu86) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
4 |
nM |
|
|
increased |
8.76% |
14.9 |
13.7 |
days |
mean |
20 |
℃ |
|
daf-16 (mu86) lifespan treated with ascr#3 (4 nM) was 9% greater than control daf-16 (mu86). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5315) |
16 |
OB_004656 |
Caenorhabditis elegans |
daf-16 (mu86) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
40 |
nM |
|
|
increased |
8.76% |
14.9 |
13.7 |
days |
mean |
20 |
℃ |
|
daf-16 (mu86) lifespan treated with ascr#3 (40 nM) was 9% greater than control daf-16 (mu86). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5316) |
17 |
OB_004657 |
Caenorhabditis elegans |
daf-16 (mu86) |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
400 |
nM |
|
|
increased |
5.11% |
14.4 |
13.7 |
days |
mean |
20 |
℃ |
|
daf-16 (mu86) lifespan treated with ascr#3 (400 nM) was not significantly different than control daf-16 (mu86). |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5317) |
18 |
OB_003760 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sir-2.1 |
Caenorhabditis elegans |
177924 |
loss of function |
ok434 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
4 |
nM |
|
|
none |
3.20% |
12.9 |
12.5 |
days |
mean |
20 |
℃ |
|
sir-2.1 (ok434) lifespan treated with ascr#3 (4 nM) was not significantly different than control. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5299) |
19 |
OB_003763 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sir-2.1 |
Caenorhabditis elegans |
177924 |
loss of function |
ok434 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
0.04 |
nM |
|
|
none |
-3.20% |
12.1 |
12.5 |
days |
mean |
20 |
℃ |
|
sir-2.1 (ok434) lifespan treated with ascr#3 (0.04 nM) was not significantly different than control. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5300) |
20 |
OB_003759 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
sir-2.1 |
Caenorhabditis elegans |
177924 |
loss of function |
ok434 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Ascr#3 |
400 |
nM |
|
|
none |
-4.80% |
11.9 |
12.5 |
days |
mean |
20 |
℃ |
|
sir-2.1 (ok434) lifespan treated with ascr#3 (400 nM) was not significantly different than control. |
Ludewig et al. |
2013 |
23509272 |
doi:10.1073/pnas.1214467110 |
Lifespan Observations Database (ID: 5298) |