Compound: Clofibrate - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Clofibrate | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009145 | ||||||||||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004709 | Caenorhabditis elegans | N2 |
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increased | 16.20% | 25.1 | 21.6 | days | mean | 20 | ℃ | 10 M clofibrate increased lifespan of C. elegans N2 by approximately 16%. | Brandstädt et al. | 2013 | 23603800 | Lifespan Observations Database (ID: 5408) | ||||||||||
2 | OB_004710 | Caenorhabditis elegans | N2 |
|
increased | 6.48% | 23 | 21.6 | days | mean | 20 | ℃ | 10 M clofibrate increased lifespan of C. elegans N2 by approximately 6%. | Brandstädt et al. | 2013 | 23603800 | Lifespan Observations Database (ID: 5409) | ||||||||||
3 | OB_004708 | Caenorhabditis elegans | N2 |
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none | 4.63% | 22.6 | 21.6 | days | mean | 20 | ℃ | 1 M clofibrate had no significant effect on lifespan of C. elegans N2. | Brandstädt et al. | 2013 | 23603800 | Lifespan Observations Database (ID: 5407) | ||||||||||
4 | OB_004719 | Caenorhabditis elegans | N2 |
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none | 1.85% | 22 | 21.6 | days | mean | 20 | ℃ | 0.1 M clofibrate had no significant effect on lifespan of C. elegans N2. | Brandstädt et al. | 2013 | 23603800 | Lifespan Observations Database (ID: 5418) | ||||||||||
5 | OB_004721 | Caenorhabditis elegans | nhr-49(gk405) |
|
none | 0.00% | 11 | 11 | days | mean | 20 | ℃ | 10 M clofibrate had no significant effect on lifespan of C. elegant nhr-49(gk405). | Brandstädt et al. | 2013 | 23603800 | Lifespan Observations Database (ID: 5420) | ||||||||||
6 | OB_004723 | Caenorhabditis elegans | nhr-49(ok2165) |
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decreased | -9.84% | 11 | 12.2 | days | mean | 20 | ℃ | 10 M clofibrate reduced lifespan of C. elegans nhr-49(ok2165) by approximately 10%.. | Brandstädt et al. | 2013 | 23603800 | Lifespan Observations Database (ID: 5422) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Brandstädt S, Schmeisser K, Zarse K, Ristow M:
Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner.
Aging (Albany NY). 2013; 5: 270-5.
PubMed (ID: 23603800), PubMed Central (ID: PMC3651519)