Compound: Caffeine - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Caffeine | ||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||
Ageing Relevance Analysis | : |
|
||||||||||||||||
Ageing Factor Stable ID | : | AF_009147 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004727 | Saccharomyces cerevisiae | BY4741 |
|
increased | 20.00% | days | median | 30 | ℃ | mata | Treatment of yeast cells with the specific TORC1 inhibitor rapamycin or caffeine releases Rim15 from TORC1-Sch9-mediated inhibition and consequently increases lifespan. | Wanke et al. | 2008 | 18513215 | doi:10.1111/j.1365-2958.2008.06292.x | Lifespan Observations Database (ID: 896) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Wanke V, Cameroni E, Uotila A, Piccolis M, Urban J, Loewith R, De Virgilio C:
Caffeine extends yeast lifespan by targeting TORC1.
Mol Microbiol. 2008; 69: 277-85.
PubMed (ID: 18513215), doi:10.1111/j.1365-2958.2008.06292.x
MeSH Terms: Caffeine/pharmacology; Protein-Serine-Threonine Kinases/metabolism; Saccharomyces cerevisiae Proteins/metabolism; Saccharomyces cerevisiae/drug effects; Saccharomyces cerevisiae/physiology; Sirolimus/pharmacology