Compound: U0126 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | U0126 | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009148 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004728 | Caenorhabditis elegans | N2 |
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decreased | -12.00% | days | mean | 20 | ℃ | hermaphrodite | Addition of the MEK inhibitor U0126 to the nematode growth medium significantly decreased the life span of N2 animals. | Okuyama et al. | 2010 | 20624915 | doi:10.1074/jbc.M110.146274 | Lifespan Observations Database (ID: 927) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Okuyama T, Inoue H, Ookuma S, Satoh T, Kano K, Honjoh S, Hisamoto N, Matsumoto K, Nishida E:
The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans.
J Biol Chem. 2010; 285: 30274-81.
PubMed (ID: 20624915), PubMed Central (ID: PMC2943277), doi:10.1074/jbc.M110.146274
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/metabolism; DNA-Binding Proteins/metabolism; Longevity/physiology; MAP Kinase Signaling System/physiology; Receptor, Insulin/metabolism; Transcription Factors/metabolism