Compound: Lithocholic acid - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Compound Name | : | Lithocholic acid | ||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_009149 | ||||||||||||||||
Download | : | XML |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||
1 | OB_004729 | Saccharomyces cerevisiae | BY4742 |
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increased | 83.33% | 22 | 12 | days | mean | 30 | ℃ | matalpha | Addition of lithocholic acid increased chronological life span of BY4742 cells under standard conditions (2% glucose), as well as dietary restricted conditions (1%, 0.5%, 0.2% glucose). | Goldberg et al. | 2010 | 20622262 | Lifespan Observations Database (ID: 937) |
Homology Analysis
no homology analysis observation available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Goldberg AA, Richard VR, Kyryakov P, Bourque SD, Beach A, Burstein MT, Glebov A, Koupaki O, Boukh-Viner T, Gregg C, Juneau M, English AM, Thomas DY, Titorenko VI:
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.
Aging (Albany NY). 2010; 2: 393-414.
PubMed (ID: 20622262), PubMed Central (ID: PMC2933888)
MeSH Terms: Lithocholic Acid/physiology; Longevity/genetics; Models, Genetic; Yeasts/physiology